(Hypertension. 1995;25:464-473.)
© 1995 American Heart Association, Inc.
Articles |
Regional Heterogeneity of Arterial Structural Changes
From the Departments of Pathology (M.J.A.P.D.) and Pharmacology (J.G.R. De M.), Cardiovascular Research Institute Maastricht, University of Limburg, Maastricht, Netherlands.
Correspondence to Dr J.G.R. De Mey, Department of Pharmacology, University of Limburg, PO Box 616, 6200 MD Maastricht, Netherlands.
Abstract Arterial structural changes in experimental models of hypertension and restenosis differ between vessel types and within vessels. Inspired by the diversity of short-term functional responses to vasoactive agents, hypotheses are presented with respect to the heterogeneity of structural alterations. Considered are the multifactorial nature of smooth muscle cell growth control and the possibility that vascular smooth muscle is not homogeneous but composed of different smooth muscle cell populations. These hypotheses may help explain the origin of both intervascular and intravascular heterogeneity of vascular structural responses.
Key Words: muscle, smooth • endothelium • nerves • angiotensin II • arteries
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