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(Hypertension. 1995;25:774-778.)
© 1995 American Heart Association, Inc.
Articles |
Fatty Acids Enhance Vascular 
-Adrenergic Sensitivity
From the Division of Clinical Pharmacology, Departments of Pharmacology and Medicine, Medical University of South Carolina, Charleston (K.T.S., B.M.E.), and the Departments of Medicine and Pharmacology, University of Wisconsin, and Veterans Administration Hospital, Madison (T.L.G.).
Abstract Hypertensive patients are heavier and have a more
centralized body fat distribution, which is associated with risk factor
clustering and resistance to insulin's actions, including suppression
of plasma nonesterified fatty acids. We postulated that abnormalities
of nonesterified fatty acids contribute to the increased vascular
-adrenergic reactivity and tone observed in our previous studies of
obese hypertensive subjects. To test this hypothesis, in two separate
protocols 10% Intralipid was infused into a dorsal hand vein with
heparin to activate lipoprotein lipase and raise fatty acid levels
locally. In protocol 1, the effects of Intralipid/heparin compared with
those of 5% dextrose/heparin on dorsal hand vein sensitivity to
phenylephrine were assessed by use of the linear variable differential
transformer technique in 8 normotensive subjects. In protocol 2, the
effects of Intralipid/heparin were compared with those of
saline/heparin on hand vein responses to both phenylephrine and
angiotensin II in 11 normotensive African American women.
Intralipid/heparin reduced the dose of phenylephrine required to
produce 50% of the maximal venoconstrictor response from 582 to 137
ng/min (compared with dextrose/heparin, P<.01) in protocol
1 and from 293 to 137 ng/min (compared with saline/heparin,
P<.01) in protocol 2. Intralipid/heparin did not
significantly alter hand vein responses to angiotensin compared with
saline/heparin. These data suggest that abnormalities of nonesterified
fatty acids in obese hypertensive patients with risk factor clustering
may contribute to their increased neurovascular tone.
Key Words: fatty acids, nonesterified • receptors, adrenergic, alpha • phenylephrine
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