(Hypertension. 1995;25:913-917.)
© 1995 American Heart Association, Inc.
Articles |
Angiotensin II Increases Vascular Permeability Factor Gene Expression by Human Vascular Smooth Muscle Cells
From the Department of Medicine, University of Leicester (UK) School of Medicine.
Abstract Angiotensin II (Ang II) has been implicated in the pathogenesis of the vascular injury associated with hypertension and diabetes mellitus. Increased vascular permeability is an important early manifestation of endothelial dysfunction and the pathogenesis of atherosclerosis. How Ang II contributes to endothelial dysfunction and promotes an increase in vascular permeability is unknown but is classically attributed to its pressor actions. We demonstrate that human vascular smooth muscle cells express abundant mRNA for vascular permeability/endothelial growth factor. Vascular permeability factor is a 34- to 42-kD glycoprotein that markedly increases vascular endothelial permeability and is a potent endothelial mitogen. Ang II potently induced a concentration-dependent (maximal, 10-7 mol/L) and time-dependent increase in vascular permeability factor mRNA expression by human vascular smooth muscle cells that was maximal after 3 hours and diminished by 24 hours. Ang II–induced vascular permeability factor mRNA expression by human vascular smooth muscle cells was inhibited by the specific Ang II receptor antagonist losartan (DuP 753), confirming that this is an Ang II receptor subtype 1–mediated event. These results describe a new action of Ang II on human vascular smooth muscle, notably the induction of vascular permeability factor mRNA expression. The wide spectrum and potent activity of vascular permeability factor suggest a novel mechanism whereby Ang II could locally and directly influence the permeability, growth, and function of the vascular endothelium independent of changes in hemodynamics.
Key Words: angiotensin II • capillary permeability • endothelial growth factors • muscle, smooth, vascular • gene expression
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|
|
|
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|
|
|
|
|
|
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|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
M. Inoue, H. Itoh, M. Ueda, T. Naruko, A. Kojima, R. Komatsu, K. Doi, Y. Ogawa, N. Tamura, K. Takaya, et al. Vascular Endothelial Growth Factor (VEGF) Expression in Human Coronary Atherosclerotic Lesions : Possible Pathophysiological Significance of VEGF in Progression of Atherosclerosis Circulation, November 17, 1998; 98(20): 2108 - 2116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Goalstone, R. Natarajan, P. R. Standley, M. F. Walsh, J. W. Leitner, K. Carel, S. Scott, J. Nadler, J. R. Sowers, and B. Draznin Insulin Potentiates Platelet-Derived Growth Factor Action in Vascular Smooth Muscle Cells Endocrinology, October 1, 1998; 139(10): 4067 - 4072. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Matsuura, W. Yamochi, K.-i. Hirata, S. Kawashima, and M. Yokoyama Stimulatory Interaction Between Vascular Endothelial Growth Factor and Endothelin-1 on Each Gene Expression Hypertension, July 1, 1998; 32(1): 89 - 95. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Hernandez, J. L. Delgado, L. F. Carbonell, M. C. Perez, and T. Quesada Hemodynamic effect of 17beta -estradiol in absence of NO in ovariectomized rats: role of angiotensin II Am J Physiol Regulatory Integrative Comp Physiol, April 1, 1998; 274(4): R970 - R978. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Otani, H. Takagi, K. Suzuma, and Y. Honda Angiotensin II Potentiates Vascular Endothelial Growth Factor–Induced Angiogenic Activity in Retinal Microcapillary Endothelial Cells Circ. Res., March 23, 1998; 82(5): 619 - 628. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kim, R. Y. Imdad, A. H. Stephenson, R. S. Sprague, and A. J. Lonigro Vascular Endothelial Growth Factor mRNA in Pericytes Is Upregulated by Phorbol Myristate Acetate Hypertension, January 1, 1998; 31(1): 511 - 515. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Natarajan, W. Bai, L. Lanting, N. Gonzales, and J. Nadler Effects of high glucose on vascular endothelial growth factor expression in vascular smooth muscle cells Am J Physiol Heart Circ Physiol, November 1, 1997; 273(5): H2224 - H2231. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
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 R. O SCHLINGEMANN and V. W M VAN HINSBERGH Role of vascular permeability factor/vascular endothelial growth factor in eye disease Br J Ophthalmol, June 1, 1997; 81(6): 501 - 512. [Full Text] [PDF]
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|
|
|
|
|
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B. Erdmann, K. Fuxe, and D. Ganten Subcellular Localization of Angiotensin II Immunoreactivity in the Rat Cerebellar Cortex Hypertension, November 1, 1996; 28(5): 818 - 824. [Abstract] [Full Text]
|
|
|
|
|
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|
|
|
|
|
|
Q. Zhao, K. Egashira, S. Inoue, M. Usui, S. Kitamoto, W. Ni, M. Ishibashi, K.-i. Hiasa, T. Ichiki, M. Shibuya, et al. Vascular Endothelial Growth Factor Is Necessary in the Development of Arteriosclerosis by Recruiting/Activating Monocytes in a Rat Model of Long-Term Inhibition of Nitric Oxide Synthesis Circulation, March 5, 2002; 105(9): 1110 - 1115. [Abstract] [Full Text] [PDF]
|
|