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(Hypertension. 1996;27:259-264.)
© 1996 American Heart Association, Inc.

Articles

Endothelin-1 and Its Receptor in Hypertrophic Cardiomyopathy

Koji Hasegawa; Hisayoshi Fujiwara; Masatoshi Koshiji; Tsukasa Inada; Seiji Ohtani; Kiyoshi Doyama; Masaru Tanaka; Akira Matsumori; Takako Fujiwara; Gotaro Shirakami; Kiminori Hosoda; Kazuwa Nakao; Sigetake Sasayama

From The Third (K. Hasegawa, T.I., S.O., K.D., M.T., A.M., S.S.) and Second (G.S., K. Hosoda, K.N.) Divisions, Department of Medicine, Kyoto (Japan) University School of Medicine; The Second Division, Department of Medicine, Gifu (Japan) University School of Medicine (H.F., M.K.); and the Kyoto (Japan) Women's University (T.F.).

Correspondence to Hisayoshi Fujiwara, MD, The Second Division, Department of Medicine, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu, 500, Japan.

Abstract Endothelin-1, a potent vasoconstrictor produced by vascular endothelial cells, activates the hypertrophic program in cultured heart muscle cells. However, the role of endothelin-1 in cardiac hypertrophy in humans is unknown. Therefore, we studied hypertrophic cardiomyopathy patients with normal pulmonary arterial pressure, in whom cardiac hypertrophy is a specific feature of the disease. Radioimmunoassay with a monoclonal antibody to human endothelin-1 showed that the plasma level of immunoreactive endothelin was more than twofold higher in hypertrophic cardiomyopathy patients than in control subjects (P<.005). In situ hybridization analysis of endomyocardial biopsy specimens showed positive signals of endothelin-1 type A receptor mRNA in ventricular myocytes of all specimens. The receptor expression in ventricular myocytes was similar between hypertrophic cardiomyopathy patients and control subjects. We propose that endothelin-1 might represent an important factor involved in hypertrophic cardiomyopathy. Whether endothelin-1 plays a causal role in cardiac hypertrophy or is a marker of its occurrence needs to be clarified.

Key Words: heart hypertrophy • receptors, endothelin • cardiomyopathy, hypertrophic

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