This Article Full Text Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hiraga, H. Articles by Kajiyama, G. Search for Related Content PubMed PubMed Citation Articles by Hiraga, H. Articles by Kajiyama, G.

(Hypertension. 1996;27:569-572.)
© 1996 American Heart Association, Inc.

Articles

Angiotensin I–Converting Enzyme Gene Polymorphism and Salt Sensitivity in Essential Hypertension

Hiroyuki Hiraga; Tetsuya Oshima; Mitsuaki Watanabe; Mari Ishida; Takafumi Ishida; Tetsuji Shingu; Masayuki Kambe; Hideo Matsuura; Goro Kajiyama

From the First Department of Internal Medicine (H.H., M.W., M.I., T.I., T.S., H.M., G.K.) and Department of Clinical Laboratory Medicine (T.O., M.K.), Hiroshima (Japan) University School of Medicine.

Correspondence to Hiroyuki Hiraga, MD, First Department of Internal Medicine, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, Hiroshima 734, Japan.

Abstract We undertook the present study in 66 Japanese patients with essential hypertension to identify genetic factors associated with salt sensitivity. Patients were classified into salt-sensitive or salt-resistant groups on the basis of changes in their mean blood pressures from a week of a low salt diet (50 mmol/d) to a week of a high salt diet (340 mmol/d). Salt sensitivity and resistance were studied in relation to a 287-bp insertion/deletion (I/D) polymorphism of the angiotensin I–converting enzyme gene detected by a polymerase chain reaction method and the haptoglobin phenotype determined by polyacrylamide gel electrophoresis. Patients with the angiotensin I–converting enzyme gene genotype II were more apt to be salt sensitive than patients with the ID and DD genotypes, although plasma renin activity was similar in each group. The frequency of the I allele in the salt-sensitive group was significantly higher than that in the salt-resistant group (²=7.4, odds ratio=2.78). However, there was no significant relationship between haptoglobin phenotype and salt sensitivity. These data suggest that an I/D polymorphism of the angiotensin I–converting enzyme gene is a genetic factor associated with salt sensitivity of blood pressure independently of plasma renin activity in Japanese patients with essential hypertension.

Key Words: hypertension, essential • angiotensin-converting enzyme • haptaglobin • genetics • sodium

This article has been cited by other articles:

				M. T. Sciarrone, P. Stella, C. Barlassina, P. Manunta, C. Lanzani, G. Bianchi, and D. Cusi ACE and {alpha}-Adducin Polymorphism as Markers of Individual Response to Diuretic Therapy Hypertension, March 1, 2003; 41(3): 398 - 403. [Abstract] [Full Text] [PDF]

				T. A. Kotchen, U. Broeckel, C. E. Grim, P. Hamet, H. Jacob, M. L. Kaldunski, J. M. Kotchen, N. J. Schork, P. J. Tonellato, and A. W. Cowley Jr Identification of Hypertension-Related QTLs in African American Sib Pairs Hypertension, November 1, 2002; 40(5): 634 - 639. [Abstract] [Full Text] [PDF]

				E. Poch, D. Gonzalez, V. Giner, E. Bragulat, A. Coca, and A. de la Sierra Molecular Basis of Salt Sensitivity in Human Hypertension: Evaluation of Renin-Angiotensin-Aldosterone System Gene Polymorphisms Hypertension, November 1, 2001; 38(5): 1204 - 1209. [Abstract] [Full Text] [PDF]

				A. K. Agarwal, G. Giacchetti, G. Lavery, H. Nikkila, M. Palermo, M. Ricketts, C. McTernan, G. Bianchi, P. Manunta, P. Strazzullo, et al. CA-Repeat Polymorphism in Intron 1 of HSD11B2 : Effects on Gene Expression and Salt Sensitivity Hypertension, August 1, 2000; 36(2): 187 - 194. [Abstract] [Full Text] [PDF]

				V. Giner, E. Poch, E. Bragulat, J. Oriola, D. Gonzalez, A. Coca, and Alejandro de la Sierra Renin-Angiotensin System Genetic Polymorphisms and Salt Sensitivity in Essential Hypertension Hypertension, January 1, 2000; 35(1): 512 - 517. [Abstract] [Full Text] [PDF]

				R. E. Pratt and V. J. Dzau Genomics and Hypertension : Concepts, Potentials, and Opportunities Hypertension, January 1, 1999; 33(1): 238 - 247. [Abstract] [Full Text] [PDF]