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(Hypertension. 1996;27:653-657.)
© 1996 American Heart Association, Inc.

Articles

Impaired Renal Vasodilation and Urinary cGMP Excretion in Dahl Salt-Sensitive Rats

Shlomoh Simchon; William Manger; Gabriele Blumberg; Jeffrey Brensilver; Stanley Cortell

From the Department of Medicine, New York University Medical Center (S.S., W.M.), the College of Physicians and Surgeons, Columbia University (S.S., S.C.), and the Division of Nephrology, St Luke's/Roosevelt Hospital (S.S., G.B., J.B., S.C.), New York, NY.

Correspondence to Dr Shlomoh Simchon, Division of Nephrology, Minturn 205, St Luke's/Roosevelt Hospital, 1111 Amsterdam Ave, New York, NY 10025.

Abstract We previously have shown that Dahl salt-sensitive rats increase renal vascular resistance in response to excessive salt feeding before total peripheral resistance increases and hypertension occurs. Failure of renal vasculature to dilate, as normally occurs in Dahl salt-resistant rats fed a high salt diet, may play a role in the development of hypertension in Dahl salt-sensitive rats. We also showed that renal vasculature in salt-sensitive rats is hyperreactive to vasoconstrictors and hyporeactive to vasodilators. Atrial natriuretic peptide, by stimulating cell-bound receptors, and nitroprusside, by generating nitric oxide, cause renal vasodilation by generating cGMP. Studies were undertaken to determine whether defective renal vasodilation in Dahl salt-sensitive rats is due to impaired production of cGMP. We examined the influence of nitroprusside infusion and salt intake on renal vascular resistance and cGMP excretion in salt-sensitive and salt-resistant rats. Results demonstrate that salt feeding and nitroprusside infusion increase cGMP excretion and decrease renal vascular resistance in salt-resistant rats (P<.01), and, although this relationship was less clear in salt-sensitive rats, there was a reciprocal relationship between renal vascular resistance and cGMP excretion in all animals studied. Salt feeding and nitroprusside infusion caused less of an increase in cGMP excretion in salt-sensitive than in salt-resistant rats (P<.01). In conclusion, these studies support the concept that impairment in cGMP generation may play a primary role in the inability of the kidneys of Dahl salt-sensitive rats to vasodilate in response to increased salt intake. Such an impairment could contribute to salt retention and the development of hypertension.

Key Words: cyclic GMP • microspheres • nitric oxide • nitroprusside • vascular resistance, renal

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