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Hypertension. 1996;27:1025-1029

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(Hypertension. 1996;27:1025-1029.)
© 1996 American Heart Association, Inc.

Articles

Mechanisms of Transcriptional Synergism of Eukaryotic Genes

The Interferon-ß Paradigm

Dimitris Thanos

From the Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY.

Correspondence to Dimitris Thanos, Department of Biochemistry and Molecular Biophysics, Columbia University, 630 W 168th St, New York, NY 10032.

Abstract The virus-inducible enhancer of the human interferon-ß gene has served as an excellent example for the mechanisms controlling the activation and repression of transcription. This enhancer is activated by three different transcription factors that, with the help of the high mobility group protein HMG I(Y), assemble in a unique nucleoprotein complex that interacts as a unit with the basal transcriptional machinery. The assembly of unique enhancer complexes from similar sets of transcription factors may provide the specificity required for regulation of complex patterns of gene expression in higher eukaryotes.


Key Words: transcription, genetic • genes, eukaryotic • interferon-beta




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