| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Hypertension. 1996;27:1210-1215.)
© 1996 American Heart Association, Inc.
Articles |
Association of Hypertension with ß2- and 
2c10-Adrenergic Receptor Genotype
From the Departments of Medicine (L.P.S., P.Z.T.) and Pediatrics (L.P., Y.-T.C.), Duke University Medical Center, Durham, NC, and National Institutes of Health, Bethesda, Md (N.B.A.).
Abstract The adrenergic receptors have been implicated in the
pathogenesis of essential hypertension. We hypothesized that
hypertension is associated with variants at the
ß2-adrenergic receptor locus and at one of the
2-adrenergic receptor loci. In unrelated individuals, we
measured untreated blood pressure and characterized each subject as
hypertensive or normotensive. We then used genomic DNA to identify
ß2- and 2c10-adrenergic receptor
restriction fragment length polymorphisms. In 175 subjects (49%
with hypertension, 55% black), both hypertension and race were
associated with genotype at the ß2 locus
(
2 for hypertension=11, P=.004;
2 for race=8.8, P=.012). The
association with hypertension persisted in each race group separately
(blacks only: 2=9.6, P=.008; whites
only: 2=14.2, P=.001). This
association persisted in a logistic model that controlled for race
(P=.01). Genotype was also significantly associated
with baseline systolic, diastolic, and mean
arterial blood pressures (P=.05, .01, and .02,
respectively). These data suggest that the ß2-adrenergic
receptor gene is a candidate gene for hypertension in blacks and
whites. We also genotyped subjects at the
2-adrenergic receptor coded on chromosome 10. There was
no association between hypertension and genotype at the
2c10 locus in the total group or in blacks, but there
was significant association in whites
(2=6.7, P=.03). These data suggest
that the ß2- and 2c10-adrenergic receptor
genes may contribute, in a race-specific manner, to the inheritance
of essential hypertension. Linkage studies in related individuals are
needed to confirm these findings.
Key Words: receptors, adrenergic • hypertension, essential • genetics • race
This article has been cited by other articles:
 |
|
 |
|
  L. Pojoga, N. S. Kolatkar, J. S. Williams, T. S. Perlstein, X. Jeunemaitre, N. J. Brown, P. N. Hopkins, B. A. Raby, and G. H. Williams {beta}-2 Adrenergic Receptor Diplotype Defines a Subset of Salt-Sensitive Hypertension Hypertension, November 1, 2006; 48(5): 892 - 900. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Small, K. M. Brown, C. A. Seman, C. T. Theiss, and S. B. Liggett Complex haplotypes derived from noncoding polymorphisms of the intronless {alpha}2A-adrenergic gene diversify receptor expression PNAS, April 4, 2006; 103(14): 5472 - 5477. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B-Y Xu, L Arlehag, S-B Rantapaa-Dahlquist, and A K Lefvert {beta}2 Adrenoceptor gene single nucleotide polymorphisms are associated with rheumatoid arthritis in northern Sweden Ann Rheum Dis, May 1, 2005; 64(5): 773 - 776. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Kirstein and P. A. Insel Autonomic Nervous System Pharmacogenomics: A Progress Report Pharmacol. Rev., March 1, 2004; 56(1): 31 - 52. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. D. McCole, A. R. Shuldiner, M. D. Brown, G. E. Moore, R. E. Ferrell, K. R. Wilund, A. Huberty, L. W. Douglass, and J. M. Hagberg {beta}2- and {beta}3-Adrenergic receptor polymorphisms and exercise hemodynamics in postmenopausal women J Appl Physiol, February 1, 2004; 96(2): 526 - 530. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. D. Tang and J. Tan Downregulation of profilin with antisense oligodeoxynucleotides inhibits force development during stimulation of smooth muscle Am J Physiol Heart Circ Physiol, October 1, 2003; 285(4): H1528 - H1536. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. Tang and J. Tan Role of Crk-Associated Substrate in the Regulation of Vascular Smooth Muscle Contraction Hypertension, October 1, 2003; 42(4): 858 - 863. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. D Garovic, M. J Joyner, N. M Dietz, E. Boerwinkle, and S. T Turner {beta}2-Adrenergic receptor polymorphism and nitric oxide-dependent forearm blood flow responses to isoproterenol in humans J. Physiol., January 15, 2003; 546(2): 583 - 589. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Kato, T. Sugiyama, H. Morita, H. Kurihara, T. Sato, Y. Yamori, and Y. Yazaki Association Analysis of {beta}2-Adrenergic Receptor Polymorphisms With Hypertension in Japanese Hypertension, February 1, 2001; 37(2): 286 - 292. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Hamet, N. Thorin-Trescases, P. Moreau, P. Dumas, B.-S. Tea, D. deBlois, V. Kren, M. Pravenec, J. Kunes, Y. Sun, et al. Workshop: Excess Growth and Apoptosis : Is Hypertension a Case of Accelerated Aging of Cardiovascular Cells? Hypertension, February 1, 2001; 37(2): 760 - 766. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Dimsdale Stalked by the Past: The Influence of Ethnicity on Health Psychosom Med, March 1, 2000; 62(2): 161 - 170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. A. Treiber, R. W. Jackson, H. Davis, J. S. Pollock, G. Kapuku, G. A. Mensah, and D. M. Pollock Racial Differences in Endothelin-1 at Rest and in Response to Acute Stress in Adolescent Males Hypertension, March 1, 2000; 35(3): 722 - 725. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Busjahn, G.-H. Li, H.-D. Faulhaber, M. Rosenthal, A. Becker, E. Jeschke, H. Schuster, B. Timmermann, M. R. Hoehe, and F. C. Luft {beta}-2 Adrenergic Receptor Gene Variations, Blood Pressure, and Heart Size in Normal Twins Hypertension, February 1, 2000; 35(2): 555 - 560. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Büscher, V. Herrmann, K. M. Ring, M. T. Kailasam, D. T. O'Connor, R. J. Parmer, and P. A. Insel Variability in Phenylephrine Response and Essential Hypertension: A Search for Human alpha 1B-Adrenergic Receptor Polymorphisms J. Pharmacol. Exp. Ther., November 1, 1999; 291(2): 793 - 798. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. C. Michel, C. Plogmann, T. Philipp, and O.-E. Brodde Functional correlates of {alpha}2A-adrenoceptor gene polymorphism in the HANE study Nephrol. Dial. Transplant., November 1, 1999; 14(11): 2657 - 2663. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Dzimiri Regulation of beta -Adrenoceptor Signaling in Cardiac Function and Disease Pharmacol. Rev., September 1, 1999; 51(3): 465 - 502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Gratze, J. Fortin, R. Labugger, A. Binder, P. Kotanko, B. Timmermann, F. C Luft, M. R Hoehe, and F. Skrabal ß-2 Adrenergic Receptor Variants Affect Resting Blood Pressure and Agonist-Induced Vasodilation in Young Adult Caucasians Hypertension, June 1, 1999; 33(6): 1425 - 1430. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. F. Schäfers, J. Nürnberger, B. Herrmann, R. R. Wenzel, T. Philipp, and M. C. Michel Adrenoceptors Mediating the Cardiovascular and Metabolic Effects of alpha -Methylnoradrenaline in Humans J. Pharmacol. Exp. Ther., May 1, 1999; 289(2): 918 - 925. [Abstract] [Full Text]
|
|
|
|
|
|
S. Takami, Z. Y. H. Wong, M. Stebbing, and S. B. Harrap Linkage analysis of glucocorticoid and beta 2-adrenergic receptor genes with blood pressure and body mass index Am J Physiol Heart Circ Physiol, April 1, 1999; 276(4): H1379 - H1384. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. P. Makaritsis, D. E. Handy, C. Johns, B. Kobilka, I. Gavras, and H. Gavras Role of the {alpha}2B-Adrenergic Receptor in the Development of Salt-Induced Hypertension Hypertension, January 1, 1999; 33(1): 14 - 17. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Kotanko, A. Binder, J. Tasker, P. DeFreitas, S. Kamdar, A. J. L. Clark, F. Skrabal, and M. Caulfield Essential Hypertension in African Caribbeans Associates With a Variant of the ß2-Adrenoceptor Hypertension, October 1, 1997; 30(4): 773 - 776. [Abstract] [Full Text]
|
|
|
|
|
|
L. P. Svetkey, Y.-T. Chen, S. P. McKeown, L. Preis, and A. F. Wilson Preliminary Evidence of Linkage of Salt Sensitivity in Black Americans at the ß2-Adrenergic Receptor Locus Hypertension, April 1, 1997; 29(4): 918 - 922. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. M. Small, S. L. Forbes, K. M. Brown, and S. B. Liggett An Asn to Lys Polymorphism in the Third Intracellular Loop of the Human alpha 2A-Adrenergic Receptor Imparts Enhanced Agonist-promoted Gi Coupling J. Biol. Chem., December 1, 2000; 275(49): 38518 - 38523. [Abstract] [Full Text] [PDF]
|
|