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(Hypertension. 1996;28:335-340.)
© 1996 American Heart Association, Inc.

Articles

Salt Intake and Plasma Atrial Natriuretic Peptide and Nitric Oxide in Hypertension

Vito M. Campese; Medhat Tawadrous; Roberto Bigazzi; Stefano Bianchi; Amardeep S. Mann; Suzanne Oparil; Leopoldo Raij

the University of Southern California, Los Angeles (V.M.C., A.M.); Unita' Operativa, Livorno, Italy (R.B., S.B.); University of Alabama, Birmingham (S.O.); and VA Medical Center, University of Minnesota, Minneapolis (L.R.).

Correspondence to Vito M. Campese, MD, LAC/USC Medical Center, 2025 Zonal Ave, Los Angeles, CA 90033.

In response to a high salt intake, salt-sensitive hypertensive individuals retain more sodium and manifest a rise in blood pressure greater than that in salt-resistant individuals. In this study, we tested whether salt sensitivity might be related at least in part to reduced secretion of atrial natriuretic peptide (ANP) or to abnormal nitric oxide production. We measured plasma ANP and NO₂+NO₃ in 7 normotensive individuals and 13 salt-sensitive and 14 salt-resistant blacks with essential hypertension under conditions of low (10 mEq/d) and high (250 mEq/d) salt intake. To evaluate possible racial differences in ANP secretion, we also measured plasma ANP in 6 salt-sensitive and 8 salt-resistant hypertensive whites during low and high salt intakes. Under low salt conditions, plasma ANP levels were not different in normotensive control subjects and salt-sensitive and salt-resistant hypertensive blacks. During high salt intake, plasma ANP levels did not change in control subjects and salt-resistant patients but decreased in salt-sensitive patients. ANP levels after high salt diet were lower (P<.01) in salt-sensitive than salt-resistant blacks. In hypertensive whites, high salt intake caused no significant change in plasma ANP. Under low salt conditions, plasma NO₂+NO₃ levels were higher (P<.05) in salt-sensitive (189±7.9 µmol/L) and salt-resistant (195±13.5 µmol/L) black patients than in control subjects (108±9.7 µmol/L). During high salt intake, plasma NO₂+NO₃ decreased significantly (P<.01) in both salt-sensitive (150±7.0 µmol/L) and salt-resistant (142±9.0 µmol/L) patients. These studies show that under conditions of high salt intake, salt-sensitive hypertensive blacks manifest a paradoxical decrease in ANP secretion. This abnormality may play a role in the reduced ability of these individuals to excrete a sodium load and in the sodium-induced rise in blood pressure. This study does not support the hypothesis that salt sensitivity depends on a deficit of nitric oxide production, but it suggests that high salt intake may alter the endothelium-dependent adaptation of peripheral resistance vessels.

Key Words: natriuretic peptides • nitric oxide • hypertension, sodium-dependent • sodium, dietary • endothelium-derived factor • blacks

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