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(Hypertension. 1996;28:1076-1080.)
© 1996 American Heart Association, Inc.

Articles

Angiotensin II Type 1 Receptor A/C¹¹⁶⁶ Polymorphism

Relationships With Blood Pressure and Cardiovascular Structure

Maurizio Castellano; Maria Lorenza Muiesan; Marina Beschi; Damiano Rizzoni; Angelo Cinelli; Massimo Salvetti; Gianfranco Pasini; Enzo Porteri; Giorgio Bettoni; Roberto Zulli; Enrico Agabiti-Rosei

the Department of Scienze Mediche, University of Brescia (Italy).

Correspondence to Maurizio Castellano, MD, Scienze Mediche, University of Brescia, c/o 1 Medicina, Spedali Civili, 25100 Brescia, Italy. E-mail castell@master.cci.unibs.it.

The angiotensin II type 1 (AT₁) receptor has a key role in mediating the vasoconstrictor and growth-promoting effects of angiotensin II. It has been reported that a polymorphism of the AT₁ receptor gene (an A/C transversion at position 1166) may be associated with cardiovascular phenotypes, such as arterial blood pressure and aortic stiffness, that underlie a condition of increased cardiovascular risk. We examined a sample of 212 subjects randomly selected from a general population in northern Italy to investigate the role of AT₁ receptor gene polymorphism in the regulation of blood pressure and cardiovascular growth. We measured blood pressure (both clinic and 24-hour ambulatory recording), left ventricular mass (echocardiography), and carotid artery wall thickness (B-mode ultrasound); we assessed the AT₁ receptor genotype by polymerase chain reaction and allele-specific oligonucleotide hybridization. Blood pressure values were lower in CC homozygotes than in heterozygotes and AA homozygotes; the difference was statistically significant for clinic measurements (mean difference for mean blood pressure, -6.6 mm Hg, P=.01; 95% confidence interval, -1.6 to -11.7 mm Hg) but not for ambulatory blood pressure measurements. CC homozygotes also presented a lower incidence of a positive family history of hypertension (P=.027). No statistically significant differences among AT₁ receptor A/C¹¹⁶⁶ genotypes were observed for left ventricular mass or carotid artery wall thickness. We conclude that the present study does not support a major role of the AT₁ receptor gene A/C¹¹⁶⁶ polymorphism as a marker of conditions associated with increased cardiovascular risk.

Key Words: receptors, angiotensin • polymorphism, genetic • blood pressure • hypertrophy

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