This Article Full Text Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Brands, M. W. Articles by Hall, J. E. Search for Related Content PubMed PubMed Citation Articles by Brands, M. W. Articles by Hall, J. E. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB BENAZEPRIL HYDROCHLORIDE Medline Plus Health Information High Blood Pressure

(Hypertension. 1997;29:1014-1019.)
© 1997 American Heart Association, Inc.

Articles

Insulin-Induced Hypertension in Rats Depends on an Intact Renin-Angiotensin System

Michael W. Brands; David L. Harrison; Henry L. Keen; Angela Gardner; Eugene W. Shek; ; John E. Hall

Correspondence to Michael W. Brands, PhD, Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216-4505.

Abstract This study tested the dependence of insulin-induced hypertension in rats on a functional renin-angiotensin system. Rats were instrumented with chronic artery and vein catheters and housed in metabolic cages. After acclimation, 10 rats began receiving the angiotensin-converting enzyme inhibitor (ACEI) benazepril at 1.8 mg · kg^-1 · d^-1 via a continuous intravenous infusion that was maintained throughout the study; 8 control rats received vehicle. Four days after starting ACEI or vehicle, all rats entered a 5-day control period that was followed by a 7-day insulin infusion at 1.5 mU · kg^-1 · min^-1. Glucose was coinfused at 22 mg · kg^-1 · min^-1 to prevent hypoglycemia. Insulin infusion in control rats increased mean arterial pressure (MAP; measured 24 h/d) from an average of 101±1 to 113±2 mm Hg on day 1; MAP averaged 110±1 mm Hg for the 7-day infusion period. Glomerular filtration rate decreased, although not significantly, from 2.7±0.1 to 2.1±0.2 mL/min on day 3. Chronic ACEI decreased baseline MAP from an average of 97±1 to 79±1 mm Hg and markedly attenuated the increase in MAP during insulin. MAP averaged 81±1 mm Hg for the 7-day period and increased significantly, to 85±2 mm Hg, only on day 3. Likewise, the tendency for glomerular filtration rate to decrease was blunted. These results indicate that insulin-induced hypertension in rats depends on angiotensin II and suggest that a reduction in glomerular filtration rate contributes to the shift in pressure natriuresis.

Key Words: insulin • blood pressure • angiotensin II • glomerular filtration rate

This article has been cited by other articles:

				M. W. Brands, T. D. Bell, N. A. Rodriquez, P. Polavarapu, and D. Panteleyev Chronic glucose infusion causes sustained increases in tubular sodium reabsorption and renal blood flow in dogs Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2009; 296(2): R265 - R271. [Abstract] [Full Text] [PDF]

				M. E. Johansson, I. J. Andersson, C. Alexanderson, O. Skott, A. Holmang, and G. Bergstrom Hyperinsulinemic rats are normotensive but sensitized to angiotensin II Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2008; 294(4): R1240 - R1247. [Abstract] [Full Text] [PDF]

				S. Tiwari, S. Riazi, and C. A. Ecelbarger Insulin's impact on renal sodium transport and blood pressure in health, obesity, and diabetes Am J Physiol Renal Physiol, October 1, 2007; 293(4): F974 - F984. [Abstract] [Full Text] [PDF]

				J. Song, X. Hu, S. Riazi, S. Tiwari, J. B. Wade, and C. A. Ecelbarger Regulation of blood pressure, the epithelial sodium channel (ENaC), and other key renal sodium transporters by chronic insulin infusion in rats Am J Physiol Renal Physiol, May 1, 2006; 290(5): F1055 - F1064. [Abstract] [Full Text] [PDF]

				A. Aneja, F. El-Atat, S. I. McFarlane, and J. R. Sowers Hypertension and Obesity Recent Prog. Horm. Res., January 1, 2004; 59(1): 169 - 205. [Abstract] [Full Text]

				J. J. Kuo, O. B. Jones, and J. E. Hall Chronic cardiovascular and renal actions of leptin during hyperinsulinemia Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2003; 284(4): R1037 - R1042. [Abstract] [Full Text] [PDF]

				C. R. Claxton and M. W. Brands Nitric Oxide Opposes Glucose-Induced Hypertension by Suppressing Sympathetic Activity Hypertension, February 1, 2003; 41(2): 274 - 278. [Abstract] [Full Text] [PDF]

				M. W. Brands, A. E. Hailman, and S. M. Fitzgerald Long-Term Glucose Infusion Increases Arterial Pressure in Dogs With Cyclooxygenase-2 Inhibition Hypertension, February 1, 2001; 37(2): 733 - 738. [Abstract] [Full Text] [PDF]

				W. T. Cefalu Insulin Resistance: Cellular and Clinical Concepts Experimental Biology and Medicine, January 1, 2001; 226(1): 13 - 26. [Abstract] [Full Text]

				C. R. Claxton, M. W. Brands, S. M. Fitzgerald, and J. A. Cameron Inhibition of Nitric Oxide Synthesis Potentiates Hypertension During Chronic Glucose Infusion in Rats Hypertension, January 1, 2000; 35(1): 451 - 456. [Abstract] [Full Text] [PDF]

				Z. K. Krowicki, N. A. Nathan, and P. J. Hornby Gastric motor and cardiovascular effects of insulin in dorsal vagal complex of the rat Am J Physiol Gastrointest Liver Physiol, November 1, 1998; 275(5): G964 - G972. [Abstract] [Full Text] [PDF]

				K. Kamide, M. T. Hori, J.-H. Zhu, J. D. Barrett, P. Eggena, and M. L. Tuck Insulin-Mediated Growth in Aortic Smooth Muscle and the Vascular Renin-Angiotensin System Hypertension, September 1, 1998; 32(3): 482 - 487. [Abstract] [Full Text] [PDF]

				T.-C. Fang and W.-C. Huang Angiotensin Receptor Blockade Blunts Hyperinsulinemia-Induced Hypertension in Rats Hypertension, August 1, 1998; 32(2): 235 - 242. [Abstract] [Full Text] [PDF]

				H. L. Keen, M. W. Brands, M. J. Smith Jr, and J. E. Hall Maintenance of Baseline Angiotensin II Potentiates Insulin Hypertension in Rats Hypertension, February 1, 1998; 31(2): 637 - 642. [Abstract] [Full Text] [PDF]