(Hypertension. 1997;29:1025-1030.)
© 1997 American Heart Association, Inc.
Articles |
Two-Kidney, One Clip and One-Kidney, One Clip Hypertension in Mice
From the Division of Hypertension, University of Lausanne (Switzerland) Medical School.
Correspondence to Thierry Pedrazzini, PhD, Division of Hypertension, University of Lausanne Medical School, CH-1011 Lausanne, Switzerland. E-mail thierry.pedrazzini{at}chuv.hospvd.ch
Abstract The mouse remains the animal of choice in transgenic experiments, creating a need for methods of evaluating the physiology of genetically modified animals. We have established and characterized two murine models of renovascular hypertension known as the two-kidney, one clip and one-kidney, one clip models. The appropriate size of the clip lumen needed to induce high blood pressure was determined to be 0.12 mm. Clips with a lumen of 0.11 mm induced a high percentage of renal infarction, and clips with a 0.13-mm opening did not produce hypertension. Four weeks after clipping, two-kidney, one clip hypertensive mice exhibited blood pressure approximately 20 mm Hg higher than their sham-operated controls. After a similar period, this increase reached almost 35 mm Hg in the one-kidney, one clip model. Depending on the model, mice develop either renin-dependent or renin-independent hypertension. Both models are characterized by the development of cardiovascular hypertrophy.
Key Words: hypertension, renovascular • mice, transgenic • renin • heart • hypertrophy
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