(Hypertension. 1997;29:913-917.)
© 1997 American Heart Association, Inc.
Articles |
Long-term Effects of Neonatal Sodium Restriction on Blood Pressure
From the Department of Epidemiology and Biostatistics, Erasmus University Medical School, and the Department of Epidemiology, Municipal Health Service Rotterdam Area (A.A.J.M.H.), Rotterdam, Netherlands.
Abstract In 1980, a randomized trial was conducted among 476 Dutch newborn infants to study the effect of a low or normal sodium diet on blood pressure during the first 6 months of life. At the end of the trial, systolic blood pressure in the low sodium group (n=231) was 2.1 mm Hg lower than in the control group (n=245). To investigate whether contrasting levels of sodium intake in infancy are associated with blood pressure differences in adolescence, we measured blood pressure in 167 children from the original cohort (35%) after 15 years of follow-up. We assessed the differences in systolic and diastolic blood pressure levels between the diet groups using a multivariate regression model with adjustment for potential confounders. The adjusted systolic blood pressure at follow-up was 3.6 mm Hg lower (95% confidence interval, -6.6 to -0.5) and the diastolic pressure was 2.2 mm Hg lower (95% confidence interval, -4.5 to 0.2) in children who had been assigned to the low sodium group (n=71) compared with the control group (n=96). These findings suggest that sodium intake in infancy may be important in relation to blood pressure later in life.
Key Words: adolescence • blood pressure • sodium, dietary • follow-up studies • infant nutrition
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