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(Hypertension. 1997;29:923-929.)
© 1997 American Heart Association, Inc.

Articles

Dietary Salt Intake Modulates Angiotensin II Type 1 Receptor Gene Expression

Charlotte Schmid; Hayo Castrop; Jürgen Reitbauer; Roberto Della Bruna; ; Armin Kurtz

From the Institut für Physiologie der Universität Regensburg (Germany).

Correspondence to Dr Charlotte Schmid, Institut für Physiologie, Universität Regensburg, D-93040 Regensburg, FRG.

Abstract This study aimed to characterize the influence of dietary salt intake on the gene expression of angiotensin II type 1 (AT₁) receptor subtypes in different organs. Male Sprague-Dawley rats were fed low salt (0.2 mg/g), normal salt (6 mg/g), or high salt (40 mg/g) diets for 5, 10, and 20 days. mRNA levels for the two AT₁ receptor subtypes were determined in adrenal gland, kidney, liver, and lung. In all of the organs examined, with the exception of the adrenal glands, low salt diet led to a transient decrease in the abundance of AT_1A receptor mRNA but not of AT_1B mRNA, which reached their nadirs between days 5 and 10 of feeding. In the adrenal gland, in which the AT_1B receptor is predominant, low salt diet led to a transient increase in the expression of this receptor gene, with a maximum around day 10 of feeding. High salt diet exerted no significant influence on AT₁ receptor gene expression in these organs. These findings indicate that the rate of salt intake, in particular, a reduction of salt intake, significantly influences AT₁ receptor gene expression in an organ-, time-, and subtype-dependent fashion. It appears that AT₁ receptor subtypes are differentially influenced by low salt intake, in that AT_1B receptor gene expression increases and AT_1A receptor gene expression decreases in this situation. This differential response of AT₁ receptor gene expression may be relevant for the organism to be able to adapt to a reduction in oral salt intake.

Key Words: receptors, angiotensin II • sodium, dietary • adrenal gland • kidney • liver • lung

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