Hypertension, Vol 3, 119-125, Copyright © 1981 by American Heart Association
RA Norman Jr, TG Coleman and AC Dent
The mean arterial pressure (MAP) of nine sinoaortic denervated (SAD) and
eight control rats housed in standard-sized metabolic cages was determined
continuously via aortic cannulae and computerized data collection over 24
hours. These continuous measurements were compared with direct, mean aortic
pressure measurements and indirect, tail-cuff systolic pressure
determinations made while these rats were resting in a Lucite restrainer.
Denervated rats were studied 1 month after debuffering. Both types of
measurements made during restraint indicated that the SAD rats were
hypertensive; the MAP averaged 145 +/- 3.4 mm Hg (mean +/- SEM) in SAD rats
compared with 119 +/- 2.8 mm Hg in the control group (p less than 0.001),
and the tail-cuff pressure in SAD rats was 156 +/- 5.4 vs 121 +/- 2.7 mm Hg
in control rats (p less than 0.001). In contrast, continuous monitoring
showed that the SAD rats were normotensive; the MAP averaged 119 +/- 4.7 mm
Hg in the SAD group and 119 +/- 3.1 mm Hg in the control group. Denervation
increased pressure lability; the average 24-hour standard deviation of MAP
was 19.0 +/- 1.2 mm Hg in SAD rats vs 8.0 +/- 0.7 mm Hg in control rats (p
less than 0.001). Apparently, arterial pressure is elevated during
restraint in SAD rats because buffering by the baroreceptor reflex is
absent, and pressure measurements made under these conditions give a false
indication of hypertension.
ARTICLES
Continuous monitoring of arterial pressure indicates sinoaortic denervated rats are not hypertensive
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