This Article Full Text Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Shen, G.-Q. Articles by Ogihara, T. Search for Related Content PubMed PubMed Citation Articles by Shen, G.-Q. Articles by Ogihara, T.

(Hypertension. 1997;30:236-239.)
© 1997 American Heart Association, Inc.

Articles

Asp905Tyr Polymorphism of Protein Phosphatase 1 G Subunit Gene in Hypertension

Gong-Qing Shen; Hiroshi Ikegami; Tomomi Fujisawa; Yoichi Hamada; Kei Kamide; Hiromi Rakugi; Jitsuo Higaki; Hideyuki Murakami; Kazuaki Shimamoto; ; Toshio Ogihara

From the Department of Geriatric Medicine, Osaka University Medical School; and the Second Department of Internal Medicine, Sapporo Medical University School of Medicine (H.M., K.S.), Japan.

Correspondence to Toshio Ogihara, MD, Department of Geriatric Medicine, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565, Japan.

Abstract A possible pathogenic polymorphism in the gene for the G subunit of the glycogen-associated regulatory form of protein phosphatase 1 (PP1 G subunit), causing an Asp-to-Tyr substitution at codon 905 (Asp905Tyr), has been reported to be associated with insulin resistance and hypersecretion of insulin in the white population. Since marked heterogeneity has been reported in the association of mutations of candidate genes with essential hypertension between Japanese and other ethnic groups, we investigated the association of Asp905Tyr with essential hypertension in Japanese subjects. The frequency of the Tyr allele in Japanese control subjects (0.70) was much higher than that in the Danish population (0.10, P<1x10^-8), indicating that the Tyr allele, previously reported as a rare variant in white subjects, is a common allele in our population. The genotype distribution in Japanese hypertensive patients (n=109; Asp/Asp=0.09, Asp/Tyr=0.39, Tyr/Tyr=0.52) was not significantly different (²=0.7, df=2, P>.6) from that in normotensive control subjects (n=148; Asp/Asp=0.12, Asp/Tyr=0.36, Tyr/Tyr=0.52). Among subjects with different PP1 G subunit genotypes, there was no difference in blood pressure, serum cholesterol, plasma glucose and insulin levels, and glucose disposal rate estimated by the euglycemic hyperinsulinemic clamp test. These data indicate that the Asp905Tyr polymorphism of the PP1 G subunit is not associated with essential hypertension, nor with insulin resistance and/or hyperinsulinemia in Japanese patients with essential hypertension, suggesting that the polymorphism plays little if any role in susceptibility to insulin resistance or hypertension.

Key Words: genes • glycogen synthase • hypertension, essential • insulin resistance • genetic predisposition • phosphoprotein phosphatase

This article has been cited by other articles:

				M. Shintani, H. Ikegami, T. Fujisawa, Y. Kawaguchi, M. Ohishi, T. Katsuya, J. Higaki, K. Shimamoto, and T. Ogihara Leptin Gene Polymorphism Is Associated with Hypertension Independent of Obesity J. Clin. Endocrinol. Metab., June 1, 2002; 87(6): 2909 - 2912. [Abstract] [Full Text] [PDF]