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(Hypertension. 1997;30:345.)
© 1997 American Heart Association, Inc.

Articles

Regulation of Type 1 Angiotensin II Receptor in Adrenal Gland

Role of ₁-Adrenoreceptor

Donna H. Wang; Jingxin Qiu; Zhaoyong Hu; Yong Du

From the Department of Internal Medicine, Hypertension and Vascular Research Laboratories, University of Texas Medical Branch (Galveston).

Correspondence to Donna H. Wang, MD, Department of Internal Medicine, Hypertension and Vascular Research Laboratories, 8.104 Medical Research Bldg, University of Texas Medical Branch, Galveston, TX 77555-1065. E-mail dwang{at}utmb.edu

Abstract We have previously shown that sodium restriction upregulates the genes encoding angiotensin II receptor (AT₁) subtypes, AT_1A and AT_1B, in the adrenal gland and that this upregulation is mediated by activation of the AT₁ receptor. There are multiple interactions between the renin-angiotensin and the adrenergic nervous systems; thus, we conducted the present experiment to investigate whether low sodium-induced upregulation of adrenal AT_1A and AT_1B is modulated by the ₁-adrenoreceptor. Seven-week-old male Wistar rats were divided into four groups and given normal sodium diet (0.5%, NS), NS+prazosin (3.5 µg · kg^-1 · min^{- 1} by osmotic pump), low sodium diet (0.07%, LS), or LS+prazosin. Body weight and mean arterial pressure were not modified over the 2 weeks of treatment (P>.05). Pressor responses to bolus injection of the ₁-agonist phenylephrine were inhibited in both prazosin groups, compared with NS and LS rats (P<.05). Adrenal AT_1A mRNA, determined by Northern blot analysis, was increased in LS (P<.05) but not in NS+prazosin (P>.05), compared with NS. Prazosin enhanced the LS-induced increase of AT_1A mRNA (P<.05). Adrenal AT_1B mRNA was increased in both LS and NS+prasozin rats, compared with NS rats (P<.05). Prazosin also enhanced the LS-induced increase in AT_1B mRNA (P<.05). Therefore, blockade of ₁-adrenoreceptor results in an enhancement of LS-induced upregulation of adrenal mRNA for AT_1A and AT_1B. These data suggest that the sympathetic nervous system exerts an inhibitory action, via activation of the ₁-adrenoreceptor, on AT_1A and AT_1B gene expression in the adrenal gland during sodium depletion.

Key Words: receptors, angiotensin • receptors, adrenergic, alpha • adrenal glands • sodium, dietary

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