This Article Full Text Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Villa, E. Articles by Romero, J. C. Search for Related Content PubMed PubMed Citation Articles by Villa, E. Articles by Romero, J. C.

(Hypertension. 1997;30:664.)
© 1997 American Heart Association, Inc.

Articles

Comparative Effect of PGE₂ and PGI₂ on Renal Function

Eduardo Villa; Rafael Garcia-Robles; John Haas; Juan Carlos Romero

From Hospital Ramón y Cajal, Madrid, Spain (E.V., R.G.-R.), and the Department of Physiology and Biophysics (E.V., J.H., J.C.R.), Mayo School of Medicine and Mayo Clinic, Rochester, Minn.

Abstract Rapid degradation of prostacyclin (PGI₂) inherent to its molecular structure has long been a major limitation in assessing the natriuretic effect of this prostaglandin. The recent availability of the stable PGI₂ analogue iloprost now allows for a comparative study with prostaglandin E₂ (PGE₂). In the present study conducted in six anesthetized dogs, the intrarenal effects of two consecutive doses (1 and 4 ng · kg^-1 · min ^-1) of PGE₂ on renal blood flow, glomerular filtration rate, and urinary sodium excretion were compared with the effects of two identical doses of iloprost. The selected doses of PGE₂ were those producing a maximal natriuretic and vasodilator response without affecting mean arterial pressure. A washout period was allowed between administration of PGE₂ and iloprost. PGE₂ infusion significantly increased fractional sodium excretion from 0.69±0.1 to 2.79±1.1% and 4.27±1.2%% (P<.05), respectively. These changes in fractional sodium excretion induced by PGE₂ were associated with significant increases in renal blood flow from 151.1±62 to 185±64.3 and 185.6±64.3 mL/min (P<.05), respectively; however, no significant alterations were seen in glomerular filtration rate, from 29.5±9.4 to 35.2±12.2 and 32.7±7.8 mL/min (NS), and mean arterial pressure, from 117.6±26 to 113.9±24.1 and 112.3±24.1 mm Hg (NS) during control and PGE₂ infusion. At identical doses, sequential infusion of PGI₂ had no effect on renal blood floww and glomerular filtration rate, producing natriuresis only at the highest dose, a fractional sodium excretion from 0.69±0.1 to 0.8±0.28 mm Hg (NS) and 1.05±0.34% (P<.05), respectively. In conclusion, the present study confirms that PGE₂ exerts a natriuretic effect during increases in renal blood flow. In contrast, PGI₂ had no hemodynamic effect, and the natriuresis was markedly blunted.

Key Words: kidney • prostaglandins • natriuresis • renal blood flow • mean arterial pressure

This article has been cited by other articles:

				P. Clark, S. E. Rowland, D. Denis, M.-C. Mathieu, R. Stocco, H. Poirier, J. Burch, Y. Han, L. Audoly, A. G. Therien, et al. MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a Selective E Prostanoid Receptor 4 Antagonist, Relieves Joint Inflammation and Pain in Rodent Models of Rheumatoid and Osteoarthritis J. Pharmacol. Exp. Ther., May 1, 2008; 325(2): 425 - 434. [Abstract] [Full Text] [PDF]

				A. W. Dreisbach, J. C. Rice, S. Japa, J. W. Newman, A. Sigel, R. S. Gill, A. E. Hess, A. C. Cemo, J. P. Fonseca, B. D. Hammock, et al. Salt Loading Increases Urinary Excretion of Linoleic Acid Diols and Triols in Healthy Human Subjects Hypertension, March 1, 2008; 51(3): 755 - 761. [Abstract] [Full Text] [PDF]

				K. K. Ebenezar, F. S. Ghane, and F. G. Smith Placental-Perinatal: Effects of indomethacin on systemic and renal haemodynamics in conscious lambs Exp Physiol, May 1, 2007; 92(3): 575 - 581. [Abstract] [Full Text] [PDF]

				M. Herrera and J. L. Garvin Novel role of AQP-1 in NO-dependent vasorelaxation Am J Physiol Renal Physiol, May 1, 2007; 292(5): F1443 - F1451. [Abstract] [Full Text] [PDF]

				M. H. Ahmed, R. J. Balment, and N. Ashton Renal Action of Acute Chloroquine and Paracetamol Administration in the Anesthetized, Fluid-Balanced Rat J. Pharmacol. Exp. Ther., August 1, 2003; 306(2): 478 - 483. [Abstract] [Full Text] [PDF]

				J. D. Imig Eicosanoid regulation of the renal vasculature Am J Physiol Renal Physiol, December 1, 2000; 279(6): F965 - F981. [Abstract] [Full Text] [PDF]

				L. P. Audoly, S. L. Tilley, J. Goulet, M. Key, M. Nguyen, J. L. Stock, J. D. McNeish, B. H. Koller, and T. M. Coffman Identification of specific EP receptors responsible for the hemodynamic effects of PGE2 Am J Physiol Heart Circ Physiol, September 1, 1999; 277(3): H924 - H930. [Abstract] [Full Text] [PDF]