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(Hypertension. 1997;30:767.)
© 1997 American Heart Association, Inc.

Articles

Exercise Training in Aging

Hemodynamic, Metabolic, and Oxidative Stress Evaluations

K. L. D. De Angelis; A. R. Oliveira; A. Werner; P. Bock; A. Belló-Klein; T. G. Fernandes; A. A. Belló; M. C. Irigoyen

From the Laboratory of Cardiovascular Physiology (K.L.D.De A., A.R.O., A.W., P.B., A.B.-K., T.G.F., A.A.B., M.C.I.), Department of Physiology, Basic and Health Science Institute, University of Rio Grande do Sul, Brazil, and BIC CNPq (A.W., P.B.).

Correspondence to Maria Cláudia Irigoyen, MD, PhD, Department of Physiology, Basic and Health Science Institute, University of Rio Grande do Sul, Brazil, Rua Sarmento Leite, 500. Porto Alegre, Rio Grande do Sul 90050-170.

Abstract The effects of exercise training on hemodynamic and metabolic parameters as well as on responses to oxidative stress in aged individuals are controversial. The aim of the present study was to investigate changes in heart hate, mean arterial pressure, vasoreactivity, and plasma levels of insulin and glucose in male aged Wistar rats submitted to exercise training for 11 weeks (1 h/d; 5 d/wk) in a treadmill. The isolated heart was perfused by H₂O₂, and oxidative stress was evaluated using thiobarbituric acid reactive substances. Cardiovascular functions were recorded with a data acquisition system (CODAS, 1 kHz). Trained aged rats were bradycardic as compared with sedentary aged rats (298±7 versus 336±16 bpm) but presented similar mean arterial pressure and vasoreactivity and plasma levels of insulin and of glucose, which were quantified by radioimmunoassay and colorimetric enzymatic test. Plasma levels of insulin and of glucose ratio were increased in trained aged rats (6.9±0.7 versus 3.5±0.4 in sedentary aged rats), and the response to oxidative stress was decreased (0.4±0.1 versus 0.7±0,1 nmol/mg protein in sedentary aged rats). These results showed that exercise training produced a lower resting heart rate as well as changes in metabolic and oxidative responses. This suggests a higher myocardium protection of trained than sedentary aged rats.

Key Words: exercise training • aging • arterial pressure • glucose • insulin • oxidative stress

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