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(Hypertension. 1997;30:1089-1096.)
© 1997 American Heart Association, Inc.

Articles

Reflex Effects on Renal Nerve Activity Characteristics in Spontaneously Hypertensive Rats

Gerald F. DiBona; Susan Y. Jones; Linda L. Sawin

From the Department of Internal Medicine, University of Iowa College of Medicine, and Department of Veterans Affairs Medical Center, Iowa City, Iowa.

Correspondence to Gerald F. DiBona, MD, Dept of Internal Medicine, University of Iowa College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242. E-mail gerald-dibona{at}uiowa.edu

Abstract The effects of arterial and cardiac baroreflex activation on the discharge characteristics of renal sympathetic nerve activity were evaluated in conscious spontaneously hypertensive and Wistar-Kyoto rats. In spontaneously hypertensive rats compared with Wistar-Kyoto rats, (1) arterial baroreflex regulation of renal sympathetic nerve activity was reset to a higher arterial pressure and the gain was decreased and (2) cardiac baroreflex regulation of renal sympathetic nerve activity exhibited a lower gain. With the use of sympathetic peak detection analysis, the inhibition of integrated renal sympathetic nerve activity, which occurred during both increased arterial pressure (arterial baroreflex) and right atrial pressure (cardiac baroreflex), was due to parallel decreases in peak height with little change in peak frequency in both spontaneously hypertensive and Wistar-Kyoto rats. Arterial and cardiac baroreflex inhibition of renal sympathetic nerve activity in Wistar-Kyoto and spontaneously hypertensive rats is due to a parallel reduction in the number of active renal sympathetic nerve fibers.

Key Words: sympathetic nervous system • rats, inbred strains • baroreceptor

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