This Article Full Text Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Huang, A. Articles by Koller, A. Search for Related Content PubMed PubMed Citation Articles by Huang, A. Articles by Koller, A.

(Hypertension. 1997;30:1210-1215.)
© 1997 American Heart Association, Inc.

Articles

Endothelin and Prostaglandin H₂ Enhance Arteriolar Myogenic Tone in Hypertension

An Huang; Akos Koller

From the Department of Physiology, New York Medical College, Valhalla, NY.

Abstract We hypothesized that endothelin in addition to prostaglandin (PG)H₂ may also contribute to the enhanced myogenic tone of skeletal muscle arterioles of spontaneously hypertensive (SH) rats. Changes in the diameter of isolated, cannulated arterioles (60 µm) from cremaster muscles of 30-week-old normotensive Wistar Kyoto (WKY) and SH rats were measured as a function of perfusion pressure (20 to 140 mm Hg). Pressure-induced constrictions were significantly enhanced between 60 to 140 mm Hg in arterioles of SH rats compared with those of WKY rats; at 80 and 140 mm Hg the normalized diameter of arterioles (expressed as a percentage of corresponding passive diameter) of SH rats was 11.0% and 15.4% less (P<.05) than that of WKY rats. After inhibition of thromboxane A₂–PGH₂ receptors by SQ 29,548 (10^-6 mol/L), the still enhanced myogenic response of SH arterioles was eliminated by the removal of endothelium or the administration of BQ-123 (10^-7 mol/L), an endothelin A (ET-A) receptor blocker, which also inhibited constrictions to exogenous ET-1 (10^-11 to 5x10^-10 mol/L). ET-1 elicited comparable responses in arterioles of SH and WKY rats. Thus, in SH rats the enhanced arteriolar constriction to increases in intravascular pressure seems to be due to the production of endothelium-derived constrictor factors PGH₂ and endothelin.

Key Words: hypertension, genetic • myogenic tone • arterioles • intraluminal pressure • endothelium

This article has been cited by other articles:

				Z. Bagi, N. Erdei, and A. Koller High intraluminal pressure via H2O2 upregulates arteriolar constrictions to angiotensin II by increasing the functional availability of AT1 receptors Am J Physiol Heart Circ Physiol, August 1, 2008; 295(2): H835 - H841. [Abstract] [Full Text] [PDF]

				J. B. Samora, J. C. Frisbee, and M. A. Boegehold Increased myogenic responsiveness of skeletal muscle arterioles with juvenile growth Am J Physiol Heart Circ Physiol, May 1, 2008; 294(5): H2344 - H2351. [Abstract] [Full Text] [PDF]

				C. Cseko, Z. Bagi, and A. Koller Biphasic effect of hydrogen peroxide on skeletal muscle arteriolar tone via activation of endothelial and smooth muscle signaling pathways J Appl Physiol, September 1, 2004; 97(3): 1130 - 1137. [Abstract] [Full Text] [PDF]

				P. Sonveaux, C. Dessy, P. Martinive, X. Havaux, B. F. Jordan, B. Gallez, V. Gregoire, J.-L. Balligand, and O. Feron Endothelin-1 Is a Critical Mediator of Myogenic Tone in Tumor Arterioles: Implications for Cancer Treatment Cancer Res., May 1, 2004; 64(9): 3209 - 3214. [Abstract] [Full Text] [PDF]

				E. Laemmel, E. Bonnardel-Phu, X. Hou, J. Seror, and E. Vicaut Interaction between nitric oxide and prostanoids in arterioles of rat cremaster muscle in vivo Am J Physiol Heart Circ Physiol, August 7, 2003; 285(3): H1254 - H1260. [Abstract] [Full Text] [PDF]

				M. P. Massett, Z. Ungvari, A. Csiszar, G. Kaley, and A. Koller Different roles of PKC and MAP kinases in arteriolar constrictions to pressure and agonists Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2282 - H2287. [Abstract] [Full Text] [PDF]

				H. H. Petersen, J. Choy, B. Stauffer, F. Moien-Afshari, C. Aalkjaer, L. Leinwand, B. M. McManus, and I. Laher Coronary artery myogenic response in a genetic model of hypertrophic cardiomyopathy Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2244 - H2249. [Abstract] [Full Text] [PDF]

				E. C. Eringa, C. D.A. Stehouwer, T. Merlijn, N. Westerhof, and P. Sipkema Physiological concentrations of insulin induce endothelin-mediated vasoconstriction during inhibition of NOS or PI3-kinase in skeletal muscle arterioles Cardiovasc Res, December 1, 2002; 56(3): 464 - 471. [Abstract] [Full Text] [PDF]

				T Ozaki, H Nishina, M A Hanson, and L Poston Dietary restriction in pregnant rats causes gender-related hypertension and vascular dysfunction in offspring J. Physiol., January 1, 2001; 530(1): 141 - 152. [Abstract] [Full Text] [PDF]

				Z. Ungvari and A. Koller Endothelin and Prostaglandin H2/Thromboxane A2 Enhance Myogenic Constriction in Hypertension by Increasing Ca2+ Sensitivity of Arteriolar Smooth Muscle Hypertension, November 1, 2000; 36(5): 856 - 861. [Abstract] [Full Text] [PDF]

				A. Huang, D. Sun, and A. Koller Shear Stress-Induced Release of Prostaglandin H2 in Arterioles of Hypertensive Rats Hypertension, April 1, 2000; 35(4): 925 - 930. [Abstract] [Full Text] [PDF]

				T.-D. Nguyen, P. Vequaud, and E. Thorin Effects of endothelin receptor antagonists and nitric oxide on myogenic tone and {alpha}-adrenergic-dependent contractions of rabbit resistance arteries Cardiovasc Res, August 15, 1999; 43(3): 755 - 761. [Abstract] [Full Text] [PDF]

				A. Huang, D. Sun, G. Kaley, and A. Koller Estrogen Preserves Regulation of Shear Stress by Nitric Oxide in Arterioles of Female Hypertensive Rats Hypertension, January 1, 1998; 31(1): 309 - 314. [Abstract] [Full Text] [PDF]