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(Hypertension. 1998;31:176.)
© 1998 American Heart Association, Inc.

Workshop on Vascular Biology & Hypertension: From Molecules to Humans

Integrins, Adhesion, and Cardiac Remodeling

Willa A. Hsueh; Ronald E. Law; Yung S. Do

From University of California at Los Angeles, School of Medicine, Department of Medicine, Division of Endocrinology, Diabetes and Hypertension, Los Angeles, Calif.

Correspondence to Willa A. Hsueh, MD, UCLA School of Medicine, Division of Endocrinology, Diabetes and Hypertension, 900 Veteran Avenue, Suite 24-130, Box 957073, Los Angeles, CA 90095-7073

Integrins are heterodimeric cell surface receptors that mediate a cell’s ability to perceive its environment, respond to changed in its environment, and alter its environment. When activated, these receptors form focal adhesions, which are areas of close attachment of the cells to extracellular matrix proteins in which colocalization of cytoskeletal proteins, intracellular signaling molecules, and growth factor receptors occurs. In cardiac fibroblasts, integrins mediate cell growth and adhesion. Growth factors such as angiotensin II regulate DNA synthesis, protooncogene expression, extracellular matrix production, adhesion, and other actions of cardiac fibroblasts, many of which require integrin activation. In addition to controlling growth factor and hemodynamic effects, regulation of integrin activity may be useful to affect cardiac fibrosis and the remodeling process.

Key Words: integrins • extracellular matrix • cardiac fibroblasts • angiotensin II • fibrosis

Abbreviations: ACEI = angiotensin-converting enzyme inhibitors • AII = angiotensin II • ANP = atrial natriuretic peptide • ECM = extracellular matrix • EGF = epidermal growth factor • ET = endothelin • FACK = focal adhesion kinase • JNK = jun N-terminal kinase • LVH = left ventricular hypertrophy • MAPK = mitogen-activated protein kinase • MEK = APK-ERK-kinase • NE = norepinephrine • NO = nitric oxide • OP = osteopontin • PDGF = platelet-derived growth factor • RGD = arginine-glycine-aspartic acid motif • TGF-ß = transforming growth factor beta

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