(Hypertension. 1998;31:469.)
© 1998 American Heart Association, Inc.
Scientific Contributions |
Impact of Dietary Na+ on Glycyrrhetinic Acid-Like Factors (Kidney 11ß-(HSD2)-GALFs) in Human Essential Hypertension
From the Department of Pathology and Laboratory Medicine, The Miriam Hospital, Brown University School of Medicine, Provideance, RI (D.J.M., Y.H.L.), and Department of Medicine, Brigham and Women’s Hospital, Boston, Mass (W.R.L., G.H.W.)
Correspondence to Dr. David J. Morris, Department of Pathology and Laboratory Medicine, The Miriam Hospital, 164 Summit Avenue, Providence, RI 02906. E-mail dmorris{at}rihosp.edu.
Our previous studies have shown that human urine contains glycyrrhetinic acid-like factors (GALFs) that possess inhibitory activity against kidney 11ß-hydroxysteroid dehydrogenase isoform 2 (HSD2). The present studies were undertaken to determine the impact of dietary Na+ intake on the levels of kidney 11ß(HSD2)-GALFs. The excretion of kidney 11ß(HSD2)-GALFs in 24-hour urine samples of 30 unmedicated subjects (10 normotensive and 10 high/normal-renin and 10 low-renin essential hypertensive subjects) on both 200- and 10-mmol Na+ diets was studied. No differences in the urinary levels of kidney 11ß(HSD2)-GALFs were observed among the three groups on the high-Na+ diet. However, with a low-Na+ diet, the levels of kidney 11ß(HSD2)-GALFs were significantly increased in hypertensive subjects but not in normal subjects. Levels increased from 8.3±1.4 to 17.3±2.9 and 6.7±1.3 to 10.6±1.4 carbenoxolone sodium units/d in high/normal-renin (P=.01) and low-renin hypertensive subjects (P=.07), respectively; normal subjects changed from 8.0±1.9 to 10.6±2.4. The levels of kidney 11ß(HSD2)-GALFs were significantly higher in the high/normal-renin hypertensive subjects than in either the control normotensive subjects or the low-renin hypertensive subjects when challenged with the low-Na+ diet (P<.05 by Wilcoxon rank-sum test). The greater response of the high/normal-renin hypertensive subjects indicated that they may utilize kidney 11ß(HSD2)-GALFs when challenged with a low-Na+ diet, whereas the low-renin essential hypertensive subjects do not.
Key Words: licorice • 11 ß-hydroxysteroid dehydrogenase • glycyrrhetinic acid • glycyrrhetinic acid-like factors • hypertension
Abbreviations: CBX = carbenoxolone sodium • GALF = glycyrrhetinic acid-like factor • HSD1, HSD2 = hydroxysteroid dehydrogenase isoform 1, isoform 2 • MR = mineralocorticoid receptor
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