This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kubisch, H. M. Articles by Gómez-Sánchez, E. P. Search for Related Content PubMed PubMed Citation Articles by Kubisch, H. M. Articles by Gómez-Sánchez, E. P.

(Hypertension. 1998;31:540.)
© 1998 American Heart Association, Inc.

Scientific Contributions

Modulation of Blood Pressure in the Dahl SS/jr Rat by Embryo Transfer

H. Michael Kubisch; Sumathy Mathialagan; Elise P. Gómez-Sánchez

From Department of Animal Sciences and Division of Endocrinology (H.M.K.), Department of Internal Medicine, University of Missouri-Columbia and Research Service, Harry S Truman Memorial Veterans Hospital Columbia, Missouri

Correspondence to Elise P. Gómez-Sánchez, Harry S Truman Memorial VA (151), 800 Hospital Drive, Columbia, MO 65201. E-mail intmdepg{at}showme.missouri.edu

Gestational hypertension and malnutrition are associated with hypertension and ischemic heart disease in the adult human. The impact of the gestational environment on the adult blood pressure in two well-characterized genetically homogeneous rat strains, the hypertensive SS/jr and normotensive SR/jr, was studied by cross-fostering within 6 hours of birth and by embryo transplantation with the recipient dam nursing the transplanted pups. Systolic blood pressure (BP) was measured by tail-cuff plethysmography twice a week after the age of 7 weeks. The lactational environment (cross-fostering) had no effect on blood pressure. Embryo transfer between like strains had no effect on the development of hypertension, nor did the BP of R transferred to S (RetS) differ from that of normal R or RetR. At 7 weeks of age, the BP of SetR was significantly lower than that of S or SetS (P<.01) and was similar to that of RetR and R. With age, the blood pressures of the S, SetS and SetR increased at approximately the same rate but from a significantly different baseline. Salt-sensitivity in the S and resistance in the R were not altered. The protective effect of the R gestational environment on SetR female BP was abrogated during whelping and lactation. Embryo transfer and cross-fostering did not alter the weight of rats older than 7 weeks. Because the BP of the R dams were significantly lower than that of the S dams, these studies do not distinguish between the effects of the R dams’ lower blood pressure per se and hormonal influences of the R uterus on the S blood pressure phenotype.

Key Words: hypertension • gestation • fetal environment • Dahl salt-sensitive rat

Abbreviations: cf = cross-fostered • et = embryo transferred • icv = intracerebroventricular • SHR = spontaneously hypertensive rat • SR/jr = Dahl salt-resistant normotensive rat inbred by John Rapp • SS/jr = Dahl salt-sensitive hypertensive rat inbred by John Rapp • WKY = normotensive Wister-Kyoto rat often used as the control for the SHR

This article has been cited by other articles:

				J. Zicha and J. Kunes Ontogenetic Aspects of Hypertension Development: Analysis in the Rat Physiol Rev, October 1, 1999; 79(4): 1227 - 1282. [Abstract] [Full Text] [PDF]

				E. P. Gomez-Sanchez and C. E. Gomez-Sanchez Maternal Hypertension and Progeny Blood Pressure : Role of Aldosterone and 11ß-HSD Hypertension, June 1, 1999; 33(6): 1369 - 1373. [Abstract] [Full Text] [PDF]