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(Hypertension. 1998;31:730-733.)
© 1998 American Heart Association, Inc.

Scientific Contributions

Lack of Association Between the -Adducin Locus and Essential Hypertension in the Japanese Population

Norihiro Kato; Takao Sugiyama; Toru Nabika; Hiroyuki Morita; Hiroki Kurihara; Yoshio Yazaki; ; Yukio Yamori

From the Graduate School of Human and Environmental Studies, Kyoto University (N.K., Y. Yamori); the Institute for Adult Diseases Asahi Life Foundation, Tokyo (T.S.); the Department of Laboratory Medicine, Shimane Medical University (T.N.); and the Third Department of Internal Medicine, Tokyo University (H.M., H.K., Y. Yazaki).

Correspondence to Norihiro Kato, MD, PhD, Graduate School of Human and Environmental Studies, Kyoto University, Yoshida Nihonmatsu-cho Sakyo-ku, Kyoto 606, Japan. E-mail kato{at}helios.jinkan.kyoto-u.ac.jp

Abstract—Significant linkage and association of -adducin, a cytoskeleton protein involved in transmembrane ion transport, with essential hypertension were recently shown in Caucasian populations, especially in relation to salt sensitivity. The present study investigated the relevance of this candidate gene to hypertension in a well-characterized Japanese population. A total number of 507 individuals were selected from clinic outpatients. Hypertensive subjects were defined on the basis of the individual's blood pressure readings before starting medications; the criteria included systolic blood pressure 160 mm Hg and/or diastolic blood pressure 95 mm Hg. Patients with diabetes mellitus, renal failure, and secondary forms of hypertension had been excluded. Control subjects had blood pressure values <130/85 mm Hg. The allele frequency of a genetic variant at amino acid residue 460 of -adducin (460Trp) was compared between cases and control subjects with ² statistics; in addition, the association was tested with blood pressure as a continuous variable. No significant association was found in either of the statistics tested. The 460Trp variant appeared to be relatively common in the Japanese (54% to 60%) compared with a reported prevalence of 13% to 23% in Caucasians. The present study brought up an important issue concerning the pathophysiological role of -adducin in non-Caucasian populations, given the likely ethnic variation in the nature of genetic susceptibility loci. The 460Trp variant of the -adducin gene is unlikely to have a major effect on susceptibility to hypertension in the Japanese population studied, although the present study does not exclude the involvement of -adducin in the pathogenesis of hypertension.

Key Words: hypertension, essential • case-control studies • sodium, dietary • -adducin • Japanese • genetics

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