From the Graduate Institute of Medical Sciences, Tzu Chi College of
Medicine, Hualien, Taiwan, Republic of China.
Abstract—Surgical correction of
renal artery stenosis in Goldblatt hypertension rapidly
normalizes blood pressure and increases renal function. This study was
conducted in 1-kidney, 1 clip (1K1C) Goldblatt hypertensive rats to
examine whether the unclipping-induced reversal of blood pressure and
renal function is mediated by nitric oxide (NO). The 1K1C rats were
prepared and given tap water with or without supplementation of
NG-nitro-L-arginine methyl ester
(L-NAME). Systolic blood pressure (SBP) before and after renal
artery clipping was measured with the tail-cuff method. Four weeks
later, surgical unclipping was performed while blood pressure and renal
function responses were determined. The results show that clipping the
renal artery for 4 weeks increased SBP from 140±5 to 183±6
mm Hg (P<0.05). Concurrent L-NAME treatment
accelerated and aggravated the clipping-induced increases in SBP from
138±6 to 219±8 mm Hg (P<0.05). Surgical
unclipping reduced blood pressure to normotensive levels within 2 hours
in all hypertensive rats with and without chronic or acute L-NAME
treatment. However, the magnitude of reductions in blood pressure in
the initial 1 hour after unclipping was significantly less in
L-NAME–treated rats than in nontreated rats (9±2% versus 16±1%,
P<0.05). Despite reducing blood pressure, unclipping
significantly increased glomerular filtration rate, urine
flow, and sodium and potassium excretions, but the extent of the
increases in these renal functions was significantly attenuated in
L-NAME–treated rats. These data suggest that NO production
partly contributes to the hypotensive and renal responses to unclipping
but does not mediate the reversal of renovascular hypertension of
this model.
© 1998 American Heart Association, Inc.
Scientific Contributions
Nitric Oxide Synthesis Inhibition Retards Surgical Reversal of One-Kidney Goldblatt Hypertension in Rats
Key Words: hypertension, one-kidney Goldblatt • renal artery obstruction • nitric oxide • diuresis • natriuresis
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