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(Hypertension. 1998;32:579-583.)
© 1998 American Heart Association, Inc.

Third Workshop on Structure and Function of Large Arteries: Part III

Lack of Association Between Renin-Angiotensin System, Gene Polymorphisms, and Wall Thickness of the Radial and Carotid Arteries

Xavier Girerd; Olivier Hanon; Jean Jacques Mourad; Pierre Boutouyrie; Stéphane Laurent; ; Xavier Jeunemaitre

From the Department of Internal Medicine and INSERM U337 (X.G., O.H., J.J.M.), the Department of Pharmacology and INSERM U337 (P.B., S.L.), and the Laboratory of Molecular Biology (X.J.), Broussais Hospital, Paris, France.

Correspondence to Dr Xavier Girerd, Service de Médecine Interne (Pr Michel Safar), Hôpital Broussais, 96 rue Didot, 75014, France. E-mail girerd{at}hbroussais.fr

Abstract

Abstract—To investigate the relationship between polymorphisms of the angiotensin-converting enzyme (ACE) and the angiotensin II type 1 receptor (AT₁R) genes and structural phenotypes of arteries, we studied a cohort of 340 subjects (aged 49±12 years) without evidence of cardiovascular disease and who had never been treated previously with any cardiovascular treatments. Structural phenotypes (wall thickness and internal diameter) were evaluated for the common carotid and the radial arteries using high-resolution echo-tracking devices (NIUS-02 and Wall Track System). The influence of ACE insertion/deletion (I/D) and AT₁R A/C¹¹⁶⁶ polymorphism genotypes on structural parameters was tested by ANOVA and logistic regression analysis. For the radial artery, mean wall thickness among subjects according to the ACE I/D or AT₁R A/C¹¹⁶⁶ genotypes was not different. This lack of association persisted in a logistic regression analysis or when the comparison was restricted to a subgroup of subjects potentially at high genetic risk (DD and CC or AC) compared with subjects at low genetic risk (AA and II or ID). Also, no association was observed between the carotid artery intima-media thickness and the 2 polymorphisms. In conclusion, the ACE I/D and the AT₁R A/C¹¹⁶⁶ gene polymorphisms are not markers of vascular hypertrophy in subjects with no evidence of cardiovascular disease. These results suggest that these gene polymorphisms have an undetectable role in the geometry of the radial and carotid arteries compared with usual determinants such as blood pressure and age.

Key Words: genes • angiotensin • arteries • wall thickness

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