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(Hypertension. 1999;33:238-247.)
© 1999 American Heart Association, Inc.

Scientific Contributions

Genomics and Hypertension

Concepts, Potentials, and Opportunities

Richard E. Pratt; Victor J. Dzau

From the Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.

Correspondence to Richard E. Pratt, PhD and Victor J. Dzau, MD, Laboratory of Genetic Physiology, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115. E-mail rpratt{at}bustoff.bwh.harvard.edu

Abstract—We are at the beginning of a biological revolution, spurred on by the Human Genome Project and associated studies. Within the next few years, expressed sequence tags (ESTs) representing all sequences expressed in humans will be determined and their genomic positions will be defined (STSs). The discovery of all the variants in the human genome that contribute to the genetic diversity of the human population will result in the construction of dense polymorphic maps. The rapid growth of the EST, STS, and single-nucleotide polymorphism (SNP) databases, coupled with impressive technological advances, will surely have a dramatic effect on biomedical research. In this review, we will examine the recent advances in genetics and genomics and place these within the context of medical research and patient care, with an emphasis on studies in the cardiovascular system.

Key Words: Human Genome Project • gene expression • genes • polymorphism, single-nucleotide • genetics • pharmacogenomics • proteomics

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