(Hypertension. 1999;33:266-270.)
© 1999 American Heart Association, Inc.
Scientific Contributions |
Genetic Polymorphism of CYP11B2 Gene and Hypertension in Japanese
From the First Department of Internal Medicine, Shiga University of Medical Science, Tsukinowa, Seta, Otsu-city, Shiga-ken, Japan.
Correspondence to Naoharu Iwai, MD, First Department of Internal Medicine, Shiga University of Medical Science, Tsukinowa Seta, Otsu-city 520-2192, Shiga-ken, Japan. E-mail iwai{at}suncuore.shiga-med.ac.jp
Abstract—Low-renin hypertension is characterized by a high ratio of aldosterone to plasma renin activity (ALD/PRA), which may suggest inappropriately increased aldosterone biosynthesis. The genes for the enzymes involved in aldosterone synthesis may contribute to low-renin hypertension. We investigated the associations between genetic variations of CYP11B2 (aldosterone synthase) T(-344)C and hypertension in 482 Japanese subjects. Subjects older than 50 years with a blood pressure <140/85 mm Hg were considered normotensive (n=227 subjects), and subjects younger than 65 years old with a BP >160/95 mm Hg were considered hypertensive (n=255 subjects). The frequency of the TC+CC genotypes in the normotensive group was significantly lower than in the hypertensive group. Logistic analysis on 482 subjects revealed that body mass index, gender, and the genotype of CYP11B2 T(-344)C were significantly associated with hypertension. ALD and PRA were assessed in 97 subjects with hypertension, and the TC+CC genotypes were significantly associated with higher ALD/PRA. Sixty-five subjects with hypertension were assessed by 24-hour ambulatory blood pressure monitoring, and the frequency of nondippers (a difference in mean blood pressure of <10% between the daytime [6 AM to 9 PM] and nighttime [9 PM to 6 AM] hours) was significantly higher in subjects with the TC+CC (hetero+homo mutation) genotype than in subjects with the TT (wild-type) genotype. Echocardiographic assessment (n=136) revealed that the ratio of left ventricular end-diastolic dimension to height tended to be higher in subjects with the TC+CC genotype than in subjects with the TT genotype. The present study suggests that the (-344)C allele of the CYP11B2 gene may be a genetic marker for low-renin hypertension in Japanese.
Key Words: genetics • CYP11B2 • aldosterone • renin • blood pressure monitoring, ambulatory • hypertension, low-renin
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