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(Hypertension. 1999;34:534-538.)
© 1999 American Heart Association, Inc.

Hypothesis

The Nature of Intracrine Peptide Hormone Action

Richard Re

From the Division of Research, Alton Ochsner Medical Foundation, New Orleans, La.

Abstract—Current theory holds that peptide hormone action results from hormone binding to cell-surface receptors, with the generation of intracellular second messengers. However, a growing body of evidence suggests that intracellular peptide hormone, either internalized or synthesized in situ, can exert physiologically relevant effects. These effects are diverse and poorly understood. I propose that such intracrine action can serve to modulate cellular function over time and thereby play a role in biological memory of various sorts, in the maintenance of hormonal responsiveness, and in cellular differentiation.

Key Words: intracrine • peptides • nucleus • memory • differentiation

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