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(Hypertension. 1999;34:539-545.)
© 1999 American Heart Association, Inc.
Brief Review |
Endothelial Function in Hypertension
The Role of Superoxide Anion
From the Department of Medicine and Therapeutics (M.M., A.F.D.), Gardiner Institute, Western Infirmary, Glasgow, UK; and the Department of Physiology (D.F.B.), University of Michigan, Ann Arbor.
Correspondence to Prof Anna F. Dominiczak, Department of Medicine and Therapeutics, Gardiner Institute, Western Infirmary, Glasgow G11 6NT, UK.
Abstract—Much attention has been focused on the role of nitric oxide in hypertension and cardiovascular disease. More recently, the role of superoxide anion and its interaction with nitric oxide has been investigated in this context. This review will concentrate on the role of superoxide in human and experimental hypertension, paying particular attention to the potential sources of superoxide within the vasculature and discussing some of the molecular mechanisms surrounding its production and dismutation. We discuss what is known about the human superoxide dismutase enzymes. We conclude that the balance between nitric oxide and superoxide is more important than the absolute levels of either alone.
Key Words: free radicals • nitric oxide • endothelium • hypertension, experimental
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