(Hypertension. 1999;34:1025.)
© 1999 American Heart Association, Inc.
Editorial |
| Introduction |
|---|
The Nobel Prize in Medicine was awarded to Drs Robert F. Furchgott,
Louis J. Ignarro, and Ferid Murad in 1998 for their studies that led to
the important discovery of endothelial synthesis of
nitric oxide and its role in the local vasodilation of blood vessels
and of the signaling role of nitric oxide in the
cardiovascular and nervous systems. These scientists
important contributions to the overall understanding of the local
regulation of blood flow have already made tremendous impact on our
understanding of the pathophysiology of many
cardiovascular, renal, and neurological diseases.
Indeed, the concept of endothelial dysfunction with
aging, menopause, its
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