| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Hypertension. 2000;35:637.)
© 2000 American Heart Association, Inc.
Scientific Contributions |
Effect of Age on Brachial Artery Wall Properties Differs From the Aorta and Is Gender Dependent
A Population Study
From the Department of Pharmacology (J.J.H.-S., H.A.S.B., L.M.V.B.) and Biophysics (A.P.H.), Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands, and the Hypertension and Cardiovascular Rehabilitation Unit (J.A.S., R.H.F.), Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium.
Correspondence to Janneke J. van der Heijden-Spek, MD, Department of Pharmacology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands.
Abstract—Compliance and distensibility are wall properties of large arteries, which may play a role in cardiovascular disease. The purpose of this study was to investigate whether the influence of age on these vessel wall properties differs between vascular territories and is gender-dependent. In a population sample of 498 men and women 20 to 79 years of age, diameter, distensibility, and compliance coefficient of the muscular brachial artery were measured with an echo-tracking device. Distensibility of the aorta was measured with the use of pulse-wave velocity. The effects of age and gender were assessed and adjusted for confounding factors such as mean blood pressure, pulse rate, body mass index, smoking, alcohol intake, and antihypertensive treatment. Covariance analysis showed no relation between gender and distensibility of the elastic aorta. Distensibility of the muscular brachial artery was lower in men, whereas men had a larger diameter and larger compliance of the brachial artery. With age, distensibility of the aorta decreased in both sexes to the same extent, whereas distensibility of the brachial artery did not change significantly. With age, brachial artery diameter increased; this increase was more pronounced in women. In men brachial artery compliance did not change with age, whereas in women compliance of the brachial artery increased with age. This study (1) confirms that distensibility of the aorta, an elastic artery, decreases with age. (2) In contrast to the aorta, after adjustment for confounding factors, in both men and women, no relation exists between age and distensibility of the muscular brachial artery. (3) Brachial artery diameter increase with age is more pronounced in women than in men. (4) In contrast to the well-known decrease in arterial compliance of elastic arteries with age, brachial artery compliance is not decreased with age and is increased in women. In conclusion, the effect of age on large-artery wall properties is not uniform but depends on gender and vascular territory.
Key Words: aorta • arteries • compliance • aging • gender
This article has been cited by other articles:
 |
|
 |
|
  E. M. Urbina, R. V. Williams, B. S. Alpert, R. T. Collins, S. R. Daniels, L. Hayman, M. Jacobson, L. Mahoney, M. Mietus-Snyder, A. Rocchini, et al. Noninvasive Assessment of Subclinical Atherosclerosis in Children and Adolescents: Recommendations for Standard Assessment for Clinical Research: A Scientific Statement From the American Heart Association Hypertension, November 1, 2009; 54(5): 919 - 950. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Hashimoto and S. Ito Some mechanical aspects of arterial aging: physiological overview based on pulse wave analysis Therapeutic Advances in Cardiovascular Disease, October 1, 2009; 3(5): 367 - 378. [Abstract] [PDF]
|
|
|
|
 |
|
 F. Fantin, C. J. Bulpitt, S. Bonapace, J. D. Cameron, and C. Rajkumar Is vascular stiffness associated with the diameter of the abdominal aorta? Age Ageing, July 1, 2009; 38(4): 466 - 469. [Full Text] [PDF]
|
|
|
|
 |
|
 N. Bjarnegard, H. J Arnqvist, T.;r. Lindstro;m, L. Jonasson, and T. Lanne Long-term hyperglycaemia impairs vascular smooth muscle cell function in women with type 1 diabetes mellitus Diabetes and Vascular Disease Research, January 1, 2009; 6(1): 25 - 31. [Abstract] [PDF]
|
|
|
|
 |
|
 F. Antonini-Canterin, S. Carerj, V. Di Bello, G. Di Salvo, S. La Carrubba, O. Vriz, D. Pavan, A. Balbarini, G. L. Nicolosi, and On behalf of the Research Group of the Italian Soc Arterial stiffness and ventricular stiffness: a couple of diseases or a coupling disease? A review from the cardiologist's point of view Eur J Echocardiogr, January 1, 2009; 10(1): 36 - 43. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. H.G. Henskens, A. A. Kroon, R. J. van Oostenbrugge, E. H.B.M. Gronenschild, M. M.J.J. Fuss-Lejeune, P. A.M. Hofman, J. Lodder, and P. W. de Leeuw Increased Aortic Pulse Wave Velocity Is Associated With Silent Cerebral Small-Vessel Disease in Hypertensive Patients Hypertension, December 1, 2008; 52(6): 1120 - 1126. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. F. Mitchell Effects of central arterial aging on the structure and function of the peripheral vasculature: implications for end-organ damage J Appl Physiol, November 1, 2008; 105(5): 1652 - 1660. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. H. Vanmolkot, L. M. Van Bortel, and J. N. de Hoon Altered arterial function in migraine of recent onset Neurology, May 8, 2007; 68(19): 1563 - 1570. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Fantin, A. Mattocks, C. J. Bulpitt, W. Banya, and C. Rajkumar Is augmentation index a good measure of vascular stiffness in the elderly? Age Ageing, January 1, 2007; 36(1): 43 - 48. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Laurent, J. Cockcroft, L. Van Bortel, P. Boutouyrie, C. Giannattasio, D. Hayoz, B. Pannier, C. Vlachopoulos, I. Wilkinson, H. Struijker-Boudier, et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications Eur. Heart J., November 1, 2006; 27(21): 2588 - 2605. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N Bjarnegard, C Bengtsson, J Brodszki, G Sturfelt, O Nived, and T Lanne Increased aortic pulse wave velocity in middle aged women with systemic lupus erythematosus Lupus, October 1, 2006; 15(10): 644 - 650. [Abstract] [PDF]
|
|
|
|
|
|
G. Schillaci, M. Pirro, M. R. Mannarino, G. Pucci, G. Savarese, S. S. Franklin, and E. Mannarino Relation Between Renal Function Within the Normal Range and Central and Peripheral Arterial Stiffness in Hypertension Hypertension, October 1, 2006; 48(4): 616 - 621. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Kalra, C. Rambaran, P. Chowienczyk, D. Goss, I. Hambleton, J. Ritter, A. Shah, R. Wilks, and T. Forrester Ethnic Differences in Arterial Responses and Inflammatory Markers in Afro-Caribbean and Caucasian Subjects Arterioscler Thromb Vasc Biol, November 1, 2005; 25(11): 2362 - 2367. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P.H. Whincup, J.A. Gilg, A.E. Donald, M. Katterhorn, C. Oliver, D.G. Cook, and J.E. Deanfield Arterial Distensibility in Adolescents: The Influence of Adiposity, the Metabolic Syndrome, and Classic Risk Factors Circulation, September 20, 2005; 112(12): 1789 - 1797. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Schillaci, M. Pirro, G. Vaudo, M. R. Mannarino, G. Savarese, G. Pucci, S. S. Franklin, and E. Mannarino Metabolic Syndrome Is Associated With Aortic Stiffness in Untreated Essential Hypertension Hypertension, June 1, 2005; 45(6): 1078 - 1082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Reneman, J. M. Meinders, and A. P.G. Hoeks Non-invasive ultrasound in arterial wall dynamics in humans: what have we learned and what remains to be solved Eur. Heart J., May 2, 2005; 26(10): 960 - 966. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. de Simone, S. R. Daniels, T. R. Kimball, M. J. Roman, C. Romano, M. Chinali, M. Galderisi, and R. B. Devereux Evaluation of Concentric Left Ventricular Geometry in Humans: Evidence for Age-Related Systematic Underestimation Hypertension, January 1, 2005; 45(1): 64 - 68. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Wiesmann, S. E. Petersen, P. M. Leeson, J. M. Francis, M. D. Robson, Q. Wang, R. Choudhury, K. M. Channon, and S. Neubauer Global impairment of brachial, carotid, and aortic vascular function in young smokers: Direct quantification by high-resolution magnetic resonance imaging J. Am. Coll. Cardiol., November 16, 2004; 44(10): 2056 - 2064. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Lenard, P. Studinger, B. Mersich, L. Kocsis, and M. Kollai Maturation of Cardiovagal Autonomic Function From Childhood to Young Adult Age Circulation, October 19, 2004; 110(16): 2307 - 2312. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. J. Lott, M. D. Herr, and L. I. Sinoway Effects of age on brachial artery myogenic responses in humans Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2004; 287(3): R586 - R591. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. F. Mitchell, H. Parise, J. A. Vita, M. G. Larson, E. Warner, J. F. Keaney Jr, M. J. Keyes, D. Levy, R. S. Vasan, and E. J. Benjamin Local Shear Stress and Brachial Artery Flow-Mediated Dilation: The Framingham Heart Study Hypertension, August 1, 2004; 44(2): 134 - 139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. F. Mitchell, H. Parise, E. J. Benjamin, M. G. Larson, M. J. Keyes, J. A. Vita, R. S. Vasan, and D. Levy Changes in Arterial Stiffness and Wave Reflection With Advancing Age in Healthy Men and Women: The Framingham Heart Study Hypertension, June 1, 2004; 43(6): 1239 - 1245. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. U. Ferrari, A. Radaelli, and M. Centola Invited Review: Aging and the cardiovascular system J Appl Physiol, December 1, 2003; 95(6): 2591 - 2597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Stewart, S. C. Millasseau, M. T. Kearney, J. M. Ritter, and P. J. Chowienczyk Effects of Inhibition of Basal Nitric Oxide Synthesis on Carotid-Femoral Pulse Wave Velocity and Augmentation Index in Humans Hypertension, November 1, 2003; 42(5): 915 - 918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. F. Mitchell, Y. Lacourciere, J.-P. Ouellet, J. L. Izzo Jr, J. Neutel, L. J. Kerwin, A. J. Block, and M. A. Pfeffer Determinants of Elevated Pulse Pressure in Middle-Aged and Older Subjects With Uncomplicated Systolic Hypertension: The Role of Proximal Aortic Diameter and the Aortic Pressure-Flow Relationship Circulation, September 30, 2003; 108(13): 1592 - 1598. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Cameron, C. J. Bulpitt, E. S. Pinto, and C. Rajkumar The Aging of Elastic and Muscular Arteries: A comparison of diabetic and nondiabetic subjects Diabetes Care, July 1, 2003; 26(7): 2133 - 2138. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. J. Willens, W. Davis, D. M. Herrington, K. Wade, K. Kesler, S. Mallon, W. V. Brown, J. H. C. Reiber, and J. K. Raines Relationship of Peripheral Arterial Compliance and Standard Cardiovascular Risk Factors Vascular and Endovascular Surgery, May 1, 2003; 37(3): 197 - 206. [Abstract] [PDF]
|
|
|
|
|
|
R. Dammers, F. Stifft, J. H. M. Tordoir, J. M. M. Hameleers, A. P. G. Hoeks, and P. J. E. H. M. Kitslaar Shear stress depends on vascular territory: comparison between common carotid and brachial artery J Appl Physiol, February 1, 2003; 94(2): 485 - 489. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Frick, S. P. Schwarzacher, H. F. Alber, A. Rinner, H. Ulmer, O. Pachinger, and F. Weidinger Morphologic rather than functional or mechanical sonographic parameters of the brachial artery are related to angiographically evident coronary atherosclerosis J. Am. Coll. Cardiol., November 20, 2002; 40(10): 1825 - 1830. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Hope, D. B. Tay, I. T. Meredith, and J. D. Cameron Comparison of generalized and gender-specific transfer functions for the derivation of aortic waveforms Am J Physiol Heart Circ Physiol, September 1, 2002; 283(3): H1150 - H1156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Giannattasio, F. Achilli, M. Failla, A. Capra, A. Vincenzi, F. Valagussa, and G. Mancia Radial, carotid and aortic distensibility in congestive heart failure: effects of high-dose angiotensin-converting enzyme inhibitor or low-dose association with angiotensin type 1 receptor blockade J. Am. Coll. Cardiol., April 17, 2002; 39(8): 1275 - 1282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. B. Wilkinson, D. J. Webb, J. R. Cockcroft, S. Kinlay, P. Ganz, and M. A. Creager Nitric Oxide and the Regulation of Arterial Elasticity: Right Idea, Wrong Vascular Bed? Hypertension, April 1, 2002; 39 (4): e26 - e27. [Full Text] [PDF]
|
|
|
|
|
|
D. R. Kaiser, K. Mullen, and A. J. Bank Brachial Artery Elastic Mechanics in Patients With Heart Failure Hypertension, December 1, 2001; 38(6): 1440 - 1445. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Vlachopoulos, K. Hirata, and M. F. O'Rourke Pressure-Altering Agents Affect Central Aortic Pressures More Than Is Apparent From Upper Limb Measurements in Hypertensive Patients: The Role of Arterial Wave Reflections Hypertension, December 1, 2001; 38(6): 1456 - 1460. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A Dettwyler, W. Holmes, T. Greiner, J. Sikorski, C. Dezateux, A. Holt, I. B Wilkinson, J. R Cockcroft, P. M. Dark, M.-J. Rolli, et al. Duration of breast feeding and adult arterial distensibility BMJ, September 22, 2001; 323(7314): 689 - 689. [Full Text]
|
|
|
|
|
|
K. Sevre, J. D. Lefrandt, G. Nordby, I. Os, M. Mulder, R. O. B. Gans, M. Rostrup, and A. J. Smit Autonomic Function in Hypertensive and Normotensive Subjects : The Importance of Gender Hypertension, June 1, 2001; 37(6): 1351 - 1356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Smulyan, R. G. Asmar, A. Rudnicki, G. M. London, and M. E. Safar Comparative effects of aging in men and women on the properties of the arterial tree J. Am. Coll. Cardiol., April 1, 2001; 37(5): 1374 - 1380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Benetos, K. Okuda, M. Lajemi, M. Kimura, F. Thomas, J. Skurnick, C. Labat, K. Bean, and A. Aviv Telomere Length as an Indicator of Biological Aging : The Gender Effect and Relation With Pulse Pressure and Pulse Wave Velocity Hypertension, February 1, 2001; 37(2): 381 - 385. [Abstract] [Full Text] [PDF]
|
|