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(Hypertension. 2000;35:998.)
© 2000 American Heart Association, Inc.

Scientific Contributions

Angiotensin-(1-7) Attenuates Vasoconstriction Evoked by Angiotensin II but Not by Noradrenaline in Man

Shinichiro Ueda; Satoko Masumori-Maemoto; Kazuhiro Ashino; Toshihiro Nagahara; Eiji Gotoh; Satoshi Umemura; Masao Ishii

From the Department of Medicine II, Yokohama City University School of Medicine, Yokohama, Japan.

Correspondence to Dr Shinichiro Ueda, Human Vascular Research Laboratory, Department of Medicine, Yokohama City University School of Medicine, 3-9, Fuku-ura, Kanazawa-ku, Yokohama 236-0004 Japan. E-mail sueda{at}med.yokohama-cu.ac.jp

Abstract—Angiotensin-(1-7) has been suggested to be a novel vasodilating peptide. We investigated the direct vascular effect of angiotensin-(1-7) in human forearm resistant vessels, particularly with regard to the interaction with angiotensin II, in healthy normotensive men by strain-gauge venous occlusion plethysmography with intra-arterial infusions of peptides. Intra-arterial infusion of angiotensin-(1-7) at 0.1 to 2000 pmol/min did not cause vasodilatation but rather reduced forearm blood flow by 10% at the highest dose. A placebo-controlled study showed that angiotensin-(1-7) at 0.5 to 40 nmol/min caused weak but significant vasoconstriction (P=0.0016 by ANOVA). Angiotensin-(1-7) at 100 pmol/min, but not at 10 pmol/min, significantly shifted the angiotensin II dose-response curve toward the right (mean±SD of percent changes in forearm blood flow: -19±17%, -33±22%, -55±12%, -63±10%, and -68±5% at 5, 10, 25, 50, and 100 pmol/min of angiotensin II, respectively, with saline; 5±13%, 0.9±18%, -40±16%, -54±9%, and -61±6% with angiotensin-(1-7), P=0.0021 by ANOVA). Angiotensin-(1-7) did not affect the dose-response curve of noradrenaline [3±12%, 5±16%, -20±22%, -31±18%, and -40±12% at 25, 50, 100, 300, and 600 pmol/min of noradrenaline, respectively, with saline; -4±15%, -2±23%, -29±22%, -34±16%, and -42±9% with angiotensin-(1-7)]. Our results suggest that angiotensin-(1-7) antagonizes vasoconstriction by angiotensin II in human resistant vessels and might act as an endogenous angiotensin II antagonist.

Key Words: angiotensin • angiotensin II • noradrenaline • blood flow velocity

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