(Hypertension. 2001;37:739.)
© 2001 American Heart Association, Inc.
Scientific Contributions |
C825T Polymorphism of the G Protein ß3-Subunit and Antihypertensive Response to a Thiazide Diuretic
From the Division of Hypertension, Department of Internal Medicine, Mayo Clinic and Foundation (S.T.T., G.L.S.), Rochester, Minn; Renal Division, Emory University (A.B.C.), Atlanta, Ga; and Human Genetics Center and Institute of Molecular Medicine, University of Texas-Houston Health Science Center (E.B.), Houston, Tex.
Correspondence and reprint requests to Stephen T. Turner, MD, Division of Hypertension, Department of Internal Medicine, Mayo Clinic and Foundation, 200 First St SW, Rochester, MN 55902. E-mail turner.stephen{at}mayo.edu
The T allele of the C825T polymorphism of the gene encoding the ß3-subunit of G proteins has been associated with increased sodium-hydrogen exchange and low renin in patients with essential hypertension. To assess its association with blood pressure response to diuretic therapy, we measured the C825T polymorphism in 197 blacks (134 men, 63 women) and 190 non-Hispanic whites (76 men, 114 women) with essential hypertension (mean±SD age 48±7 years), who underwent monotherapy with hydrochlorothiazide for 4 weeks. Mean declines in systolic and diastolic blood pressures were 6±2 (P<0.001) and 5±1 (P<0.001) mm Hg greater, respectively, in TT than in CC homozygotes. Responses in heterozygotes were intermediate between the homozygous groups. Other univariate predictors of greater blood pressure responses included black race, female gender, higher pretreatment blood pressure, older age, lower waist-to-hip ratio, and measures of lower renin-angiotensin-aldosterone system activity. After the effects of the other predictors were considered, the TT genotype remained a significant predictor of greater declines in systolic and diastolic blood pressures. Thus, the C825T polymorphism of the G protein ß3-subunit may help identify patients with essential hypertension who are more responsive to diuretic therapy.
Key Words: hypertension, essential • blood pressure • diuretics • proteins • genetics
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