(Hypertension. 2001;37:781.)
© 2001 American Heart Association, Inc.
Scientific Contributions |
Long-Term Antioxidant Administration Attenuates Mineralocorticoid Hypertension and Renal Inflammatory Response
From the Departments of Physiology (R.C.W.) and Anatomy (W.D.H.) and the Vascular Biology Center (H.Z., J.D.C.), Medical College of Georgia, Augusta, Ga; Department of Physiology (R.A.B.), University of Michigan (Ann Arbor); and Department of Biology (D.M.), Fort Valley State University, Fort Valley, Ga.
Correspondence to Dr Richard A. Beswick, Department of Physiology, Medical College of Georgia, Augusta, GA 30912-3000. E-mail rbeswick{at}umich.edu
We
previously reported increased monocyte/macrophage infiltration,
reactive oxygen species accumulation, and nuclear factor-
B (NF-B)
activation in mineralocorticoid (deoxycorticosterone acetate [DOCA])
hypertensive rats. We tested the hypothesis that prolonged antioxidant
administration inhibits superoxide accumulation, lowers blood pressure,
and reduces NF-B activation in DOCA-salt hypertensive rats. DOCA
rats exhibited a significant increase in systolic blood
pressure compared with sham rats. Aortic rings from DOCA rats exhibited
increased superoxide
(O2-)
production compared with sham rats. In addition, the treatment
of DOCA rats with pyrrolidinedithiocarbamate (PDTC) or
4-hydroxy-2,2,6,6-tetramethyl piperidinoxyl (Tempol) caused a
significant decrease in systolic blood pressure and aortic
superoxide accumulation. Monocyte/macrophage infiltration was
also significantly decreased in DOCA rats treated with PDTC or Tempol
compared with untreated DOCA rats. NF-B–binding activity was
significantly greater in untreated DOCA rats than in either sham rats
or PDTC- or Tempol-treated DOCA rats. Also, DOCA rats treated with
Tempol exhibited no significant difference in NF-B–binding activity
compared with sham. These results suggest that antioxidants attenuate
systolic blood pressure, suppress renal NF-B–binding
activity, and partly alleviate renal monocyte/macrophage
infiltration in DOCA-salt hypertension.
Key Words: Tempol • pyrrolidinedithiocarbamate • hypertension, mineralocorticoid • nuclear factor-B • monocyte/macrophage
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