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(Hypertension. 2002;39:886.)
© 2002 American Heart Association, Inc.

Scientific Contributions

Sympathetic Response to Ventricular Extrasystolic Beats in Hypertension and Heart Failure

Guido Grassi; Gino Seravalle; Giovanni Bertinieri; Maria Luisa Stella; Carlo Turri; Giuseppe Mancia

From the Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Università Milano -Bicocca, Ospedale San Gerardo (G.G., C.T., G.M.), Monza (Milan), Italy; Istituto Auxologico Italiano, IRCCS (G.G., G.S., G.M.), Milan, Italy; and Centro Interuniversitario di Fisiologia Clinica ed Ipertensione, Università Milano-Bicocca (G.G., G.B., M.L.S., G.M.), Milan, Italy.

Correspondence to Prof Giuseppe Mancia, Clinica Medica, Ospedale San Gerardo dei Tintori, Via Donizetti 106, 20053 Monza (Milano), Italy.

Provoked premature ventricular contractions (PVCs) evoke, in concomitance with an early and late blood pressure fall and overshoot, an early sympathoexcitation and a later period of sympathoinhibition, respectively. The present study was designed to examine whether in healthy subjects this is the case for spontaneous PVCs. Because of their pathophysiological relevance for arrhythmogenesis, it was also designed to determine whether the sympathetic responses are different from those seen in essential hypertension and congestive heart failure. In 14 untreated mild essential hypertensives (EH; age, 53.8±2.6 years; mean±SEM), 20 untreated congestive heart failure patients (CHF; age, 56.7±2.5 years; New York Heart Association class, II or III), and 16 age-matched healthy subjects (control) in Lown class <II, we evaluated the blood pressure (Finapres), heart rate (ECG), and muscle sympathetic nerve traffic (MSNA; by microneurography) responses to isolated monofocal PVCs. MSNA, quantified as bursts/100 heart beats, was significantly increased in EH (57.8±3.8, P<0.05) and CHF patients (77.7±4.0, P<0.01) compared with controls (44.6±4.4). In controls, the PVC-induced blood pressure fall and overshoot were accompanied by a sympathoexcitation (144.2±14%), followed by a period of sympathoinhibition (average duration, 12043±985 ms). The responses were similar in EH but not in CHF, in whom the magnitude of the sympathoexcitation and particularly the duration of the subsequent sympathoinhibition were strikingly reduced (average reduction, -46.1 and -72.8%, respectively). The most important factor accounting for this reduction appeared to be an altered baroreflex response to the PVC-induced BP changes. These data demonstrate that the MSNA responses to spontaneous PVCs are similar in controls and EH but markedly impaired in CHF, presumably because of the baroreflex alteration. This may represent an important factor for the genesis of the life-threatening ventricular arrhythmias that characterize CHF.

Key Words: arrhythmia • heart failure • sympathetic nervous system • baroreflex

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