Hypertension. 2002;39:1044-1049
doi: 10.1161/01.HYP.0000018580.24644.18
doi: 10.1161/01.HYP.0000018580.24644.18
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(Hypertension. 2002;39:1044.)
© 2002 American Heart Association, Inc.
Scientific Contributions |
Linkage of Essential Hypertension to Chromosome 18q
From deCODE genetics, Inc (K.K., A.M., H.K., S.I., G.T., M.L.F., A.K., J.R.G., K.S.), and the Department of Medicine, National University Hospital (Landspitalinn) (A.K., T.H.), Reykjavik, Iceland.
Correspondence to Kari Stefansson or Kristleifur Kristjansson, deCODE Genetics, Sturlugata 8, IS-101 Reykjavik, Iceland. E-mail kstefans@ decode.is or kris@ decode.is
Abstract— We performed a genomewide scan with 904 microsatellite markers using 120 extended Icelandic families with 490 hypertensive patients. The families were identified by cross-matching a list of hypertensive patients from the Hypertension Clinic of the University Hospital (Landspitalinn) in Iceland with a genealogy database of the entire Icelandic nation. After adding 5 markers, we found linkage to chromosome 18q with an allele-sharing LOD score of 4.60 (P=2.1x 10-6). These results provide evidence for a novel susceptibility gene for essential hypertension on chromosome 18q and show that it is possible to study the genetics of essential hypertension without stratifying by subphenotypes.
Key Words: genetics • population • hypertension, essential
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