This Article Full Text Full Text (PDF) Data Supplement All Versions of this Article: 41/2/368    most recent 01.HYP.0000050962.48249.B7v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Oberkofler, H. Articles by Patsch, W. Search for Related Content PubMed PubMed Citation Articles by Oberkofler, H. Articles by Patsch, W. Pubmed/NCBI databases Gene GEO Profiles HomoloGene UniGene Medline Plus Health Information High Blood Pressure Related Collections Clinical genetics Epidemiology Genetics of cardiovascular disease Risk Factors

(Hypertension. 2003;41:368.)
© 2003 American Heart Association, Inc.

Rapid Communication

Peroxisome Proliferator–Activated Receptor- Coactivator-1 Gene Locus

Associations with Hypertension in Middle-Aged Men

Hannes Oberkofler; Bertram Hölzl; Harald Esterbauer; Mingqiang Xie; Bernhard Iglseder; Franz Krempler; Bernhard Paulweber; Wolfgang Patsch

From the Department of Laboratory Medicine (H.O., H.E., M.X., W.P.), the First Department of Internal Medicine (B.H., B.P.), and the Department of Neurology (B.I.), Landeskliniken, Salzburg; and the Department of Internal Medicine, Krankenhaus Hallein (F.K.), Austria.

Correspondence to Wolfgang Patsch, MD, Department of Laboratory Medicine, Landeskliniken Salzburg, Muellner Hauptstrasse 48, A-5020 Salzburg, Austria. E-mail w.patsch{at}lks.at

Peroxisome proliferator–activated receptor- coactivator-1 (PPARGC1/PGC-1) is a transcriptional coactivator of nuclear hormone receptors implicated in blood pressure regulation. We therefore ascertained whether the PPARGC1 gene locus is associated with hypertension. We studied associations of 3 polymorphisms in PPARGC1 transcripts with hypertension in 683 middle-aged men and 530 middle-aged women of a cross-sectional Austrian population. Hypertension was defined by average values of systolic or diastolic ambulatory blood pressure readings (taken between 7 AM and 10 PM) above 140 and/or 90 and/or use of antihypertensive medication. Among the 3 polymorphic sites, genotype distributions associated with Gly482Ser differed by hypertension status in men (P=0.0038), but not in women. The less common Ser482 allele was associated with a modest, but significant, reduction in the prevalence of hypertension in men. The distribution of 3 loci haplotypes also differed in men with and without hypertension (P=0.015). Despite its moderate effect, but because of its high frequency (64%), the more common risk allele contributed to hypertension in 35% (95% CI 16% to 54%) of our male population. These results suggest, but do not prove, that PPARGC1 participates in blood pressure control, and sequence substitutions at its gene locus confer an increased risk of hypertension to a substantial proportion of men.

Key Words: genetics • genes • gender • haplotypes • polymorphism

This article has been cited by other articles:

				M. Wirtenberger, S. Tchatchou, K. Hemminki, J. Schmutzhard, C. Sutter, R. K. Schmutzler, A. Meindl, B. Wappenschmidt, M. Kiechle, N. Arnold, et al. Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer Carcinogenesis, November 1, 2006; 27(11): 2201 - 2208. [Abstract] [Full Text] [PDF]

				B. Iglseder, H. Oberkofler, T. K. Felder, K. Klein, B. Paulweber, F. Krempler, D. A. Tregouet, and W. Patsch Associations of PPARGC1A Haplotypes With Plaque Score but Not With Intima-Media Thickness of Carotid Arteries in Middle-Aged Subjects Stroke, September 1, 2006; 37(9): 2260 - 2265. [Abstract] [Full Text] [PDF]

				S Sookoian, S I Garcia, P I Porto, G Dieuzeide, C D Gonzalez, and C J Pirola Peroxisome proliferator-activated receptor gamma and its coactivator-1 alpha may be associated with features of the metabolic syndrome in adolescents J. Mol. Endocrinol., October 1, 2005; 35(2): 373 - 380. [Abstract] [Full Text] [PDF]

				G Andersen, L Wegner, K Yanagisawa, C S Rose, J Lin, C Glumer, T Drivsholm, K Borch-Johnsen, T Jorgensen, T Hansen, et al. Evidence of an association between genetic variation of the coactivator PGC-1{beta} and obesity J. Med. Genet., May 1, 2005; 42(5): 402 - 407. [Abstract] [Full Text] [PDF]

				G. Andersen, L. Wegner, D. P. Jensen, C. Glumer, L. Tarnow, T. Drivsholm, P. Poulsen, S. K. Hansen, E.-M. D. Nielsen, J. Ek, et al. PGC-1{alpha} Gly482Ser Polymorphism Associates With Hypertension Among Danish Whites Hypertension, April 1, 2005; 45(4): 565 - 570. [Abstract] [Full Text] [PDF]

				C. Weigert, C. Thamer, K. Brodbeck, A. Guirguis, F. Machicao, J. Machann, F. Schick, M. Stumvoll, A. Fritsche, H. U. Haring, et al. The -913 G/A Glutamine:Fructose-6-Phosphate Aminotransferase Gene Polymorphism Is Associated with Measures of Obesity and Intramyocellular Lipid Content in Nondiabetic Subjects J. Clin. Endocrinol. Metab., March 1, 2005; 90(3): 1639 - 1643. [Abstract] [Full Text] [PDF]

				H. Oberkofler, B. Iglseder, K. Klein, J. Unger, M. Haltmayer, F. Krempler, B. Paulweber, and W. Patsch Associations of the UCP2 Gene Locus With Asymptomatic Carotid Atherosclerosis in Middle-Aged Women Arterioscler. Thromb. Vasc. Biol., March 1, 2005; 25(3): 604 - 610. [Abstract] [Full Text] [PDF]

				H. Oberkofler, V. Linnemayr, R. Weitgasser, K. Klein, M. Xie, B. Iglseder, F. Krempler, B. Paulweber, and W. Patsch Complex Haplotypes of the PGC-1{alpha} Gene Are Associated With Carbohydrate Metabolism and Type 2 Diabetes Diabetes, May 1, 2004; 53(5): 1385 - 1393. [Abstract] [Full Text] [PDF]