This Article Full Text Full Text (PDF) All Versions of this Article: 42/5/909    most recent 01.HYP.0000097600.58083.EEv1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sartori, M. Articles by Palatini, P. Search for Related Content PubMed PubMed Citation Articles by Sartori, M. Articles by Palatini, P. Related Collections Clinical Studies

(Hypertension. 2003;42:909.)
© 2003 American Heart Association, Inc.

Scientific Contributions

G-Protein ß₃-Subunit Gene 825T Allele and Hypertension

A Longitudinal Study in Young Grade I Hypertensives

Michelangelo Sartori; Andrea Semplicini; Winfried Siffert; Paolo Mormino; Alberto Mazzer; Fabrizio Pegoraro; Lucio Mos; Mikolaj Winnicki; Paolo Palatini

From the Department of Clinical and Experimental Medicine, University of Padova (M.S., A.S., P.M., M.W., P.P.), Padova, Italy; Institut für Pharmakologie, Universitätsklinikum Essen (W.S.), Essen, Germany; Divisione Medica, Vittorio Veneto Town Hospital (A.M.), Vittorio Veneto, Italy; Divisione Medica, Dolo Town Hospital (F.P.), Dolo, Italy; and Area di Emergenza, San Daniele Town Hospital (L.M.), San Daniele del Friuli, Italy.

Correspondence to Prof Andrea Semplicini, Clinica Medica 4, Policlinico Universitario, via Giustiniani 2, 35128 Padova, Italy. E-mail andrea.semplicini{at}unipd.it

The 825T allele of the GNB3 gene has been associated with essential hypertension and obesity in cross-sectional studies. We have therefore planned a longitudinal cohort study to assess whether the GNB3 825T allele is predictive of blood pressure increase in young subjects with grade I hypertension. We genotyped at the GNB3 825 locus 461 participants of the Hypertension and Ambulatory Recording Venetia Study (HARVEST) study (age, 18 to 45 years) at low cardiovascular risk, according to 1999 ISH/WHO criteria. The study end point was eligibility for antihypertensive medication, that is, progression to grade II hypertension during the first year of observation or office systolic blood pressure 150 mm Hg and/or office diastolic blood pressure 95 mm Hg in two later consecutive visits during follow-up. At baseline, there was no statistically significant difference among genotypes with respect to body mass index, blood pressure, and heart rate. During follow-up (mean, 4.7 years), 113 (51.1%) patients with CC genotype and 145 (60.4%) patients with TT/TC genotype reached the end point. According to survival analysis, the patients carrying the 825T allele had an increased risk of reaching the blood pressure end point (CI, 1.108 to 1.843; P=0.006). In young patients with grade I hypertension, the 825T allele is associated with increased risk of progression to more severe hypertension requiring antihypertensive therapy. The GNB3 825T allele may be considered a genetic marker of predisposition for hypertension.

Key Words: blood pressure monitoring, ambulatory • genetics • antihypertensive therapy • hypertension, genetic • signal transduction • GTP-binding proteins

This article has been cited by other articles:

				P. Palatini, P. Visentin, F. Dorigatti, C. Guarnieri, M. Santonastaso, S. Cozzio, F. Pegoraro, A. Bortolazzi, O. Vriz, L. Mos, et al. Regular physical activity prevents development of left ventricular hypertrophy in hypertension Eur. Heart J., January 2, 2009; 30(2): 225 - 232. [Abstract] [Full Text] [PDF]

				L. A. Calo, M. Puato, S. Schiavo, M. Zanardo, C. Tirrito, E. Pagnin, G. Balbi, P. A. Davis, P. Palatini, and P. Pauletto Absence of vascular remodelling in a high angiotensin-II state (Bartter's and Gitelman's syndromes): implications for angiotensin II signalling pathways Nephrol. Dial. Transplant., September 1, 2008; 23(9): 2804 - 2809. [Abstract] [Full Text] [PDF]

				M. Yazdanpanah, Y. S. Aulchenko, A. Hofman, J. A.M.J.L. Janssen, F. A. Sayed-Tabatabaei, R. H.N. van Schaik, O. H. Klungel, B. H.C.H. Stricker, H. A.P. Pols, J. C.M. Witteman, et al. Effects of the Renin-Angiotensin System Genes and Salt Sensitivity Genes on Blood Pressure and Atherosclerosis in the Total Population and Patients With Type 2 Diabetes Diabetes, July 1, 2007; 56(7): 1905 - 1912. [Abstract] [Full Text] [PDF]

				A. O. Adewuya, B. A. Ola, O. E. Ajayi, A. O. Oyedeji, M. O. Balogun, and S. K. Mosaku Prevalence and Correlates of Major Depressive Disorder in Nigerian Outpatients With Heart Failure Psychosomatics, December 1, 2006; 47(6): 479 - 485. [Abstract] [Full Text] [PDF]

				E. P. Havranek, J. A. Spertus, F. A. Masoudi, P. G. Jones, and J. S. Rumsfeld Predictors of the onset of depressive symptoms in patients with heart failure J. Am. Coll. Cardiol., December 21, 2004; 44(12): 2333 - 2338. [Abstract] [Full Text] [PDF]

				P. Palatini, M. Winnicki, M. Santonastaso, L. Mos, D. Longo, V. Zaetta, M. D. Follo, T. Biasion, and A. C. Pessina Prevalence and Clinical Significance of Isolated Ambulatory Hypertension in Young Subjects Screened for Stage 1 Hypertension Hypertension, August 1, 2004; 44(2): 170 - 174. [Abstract] [Full Text] [PDF]

				F. C. Luft Geneticism of Essential Hypertension Hypertension, June 1, 2004; 43(6): 1155 - 1159. [Full Text] [PDF]