This Article Full Text Full Text (PDF) All Versions of this Article: 44/4/435    most recent 01.HYP.0000142111.67601.6bv1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Nielsen, S. Articles by Jensen, M. D. Search for Related Content PubMed PubMed Citation Articles by Nielsen, S. Articles by Jensen, M. D. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Medline Plus Health Information High Blood Pressure Nutrition Obesity Hazardous Substances DB PALMITIC ACID SODIUM PALMITATE Related Collections Obesity Hypertension - basic studies Endothelium/vascular type/nitric oxide

(Hypertension. 2004;44:435.)
© 2004 American Heart Association, Inc.

Scientific Contributions

Vascular Response to Angiotensin II in Upper Body Obesity

From the Endocrine Research Unit (S.N., M.D.J.) and Anesthesia Research (J.R.H., M.J.J.), Mayo Clinic, Rochester, Minn.

Correspondence to Michael D. Jensen, MD, Mayo Clinic, Endocrine Research Unit, 200 1st Street SW, Rm 5-194 Joseph, Rochester, MN 55905. E-mail jensen.michael{at}mayo.edu

Upper body obesity is associated with insulin resistance, hypertension, and endothelial dysfunction. We examined forearm vascular function in response to vasodilator (endothelium-dependent and endothelium-independent) and vasoconstrictor stimuli in 8 normotensive, upper body/viscerally obese men with a positive family history of hypertension and 8 age-matched nonobese men. We also measured body composition and insulin regulation of free fatty acid (FFA) and glucose metabolism. Forearm blood flow was measured before and during brachial artery infusions of acetylcholine (Ach), sodium nitroprusside (NTP), and angiotensin II (±nitric oxide synthase [NO]) synthase blockade with N^G-monomethyl L-arginine [L-NMMA]). On a separate day, baseline and insulin-regulated glucose ([3-³H]glucose) and FFA ([9,10-³H]palmitate) turnover were measured. The vasoconstrictor response to angiotensin II was greater (P<0.05) in obese men than in nonobese men, whereas endothelium-dependent vasodilation was similar. The slope of the angiotensin II dose-response curve correlated significantly with the basal plasma palmitate concentration. Basal and insulin-mediated glucose disposal was significantly reduced and FFA turnover significantly increased in viscerally obese men. No differences in endothelium-independent vasodilation or relationships between vascular responsivity and palmitate and glucose kinetics or body composition were found. Angiotensin II–stimulated forearm vasoconstriction is increased in viscerally obese normotensive men.

Key Words: fatty acids • blood flow

This article has been cited by other articles:

				G. P. Van Guilder, B. L. Stauffer, J. J. Greiner, and C. A. DeSouza Impaired endothelium-dependent vasodilation in overweight and obese adult humans is not limited to muscarinic receptor agonists Am J Physiol Heart Circ Physiol, April 1, 2008; 294(4): H1685 - H1692. [Abstract] [Full Text] [PDF]

				D. W. Stepp, E. I. Boesen, J. C. Sullivan, J. D. Mintz, C. D. Hair, and D. M. Pollock Obesity augments vasoconstrictor reactivity to angiotensin II in the renal circulation of the Zucker rat Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2537 - H2542. [Abstract] [Full Text] [PDF]

				S. Shadid, J. A. Kanaley, M. T. Sheehan, and M. D. Jensen Basal and insulin-regulated free fatty acid and glucose metabolism in humans Am J Physiol Endocrinol Metab, June 1, 2007; 292(6): E1770 - E1774. [Abstract] [Full Text] [PDF]

				N. Toda, K. Ayajiki, and T. Okamura Interaction of Endothelial Nitric Oxide and Angiotensin in the Circulation Pharmacol. Rev., March 1, 2007; 59(1): 54 - 87. [Abstract] [Full Text] [PDF]

				A. L. Mundy, E. Haas, I. Bhattacharya, C. C. Widmer, M. Kretz, R. Hofmann-Lehmann, R. Minotti, and M. Barton Fat intake modifies vascular responsiveness and receptor expression of vasoconstrictors: Implications for diet-induced obesity Cardiovasc Res, January 15, 2007; 73(2): 368 - 375. [Abstract] [Full Text] [PDF]

				R. M. Brothers, M. L. Haslund, D. W. Wray, P. B. Raven, and M. Sander Exercise-induced inhibition of angiotensin II vasoconstriction in human thigh muscle J. Physiol., December 1, 2006; 577(2): 727 - 737. [Abstract] [Full Text] [PDF]

				L. Hunyady and K. J. Catt Pleiotropic AT1 Receptor Signaling Pathways Mediating Physiological and Pathogenic Actions of Angiotensin II Mol. Endocrinol., May 1, 2006; 20(5): 953 - 970. [Abstract] [Full Text] [PDF]

				S. Watanabe, T. Tagawa, K. Yamakawa, M. Shimabukuro, and S. Ueda Inhibition of the Renin-Angiotensin System Prevents Free Fatty Acid-Induced Acute Endothelial Dysfunction in Humans Arterioscler. Thromb. Vasc. Biol., November 1, 2005; 25(11): 2376 - 2380. [Abstract] [Full Text] [PDF]