This Article Full Text Full Text (PDF) All Versions of this Article: 45/3/426    most recent 01.HYP.0000157818.58878.93v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Dernellis, J. Articles by Panaretou, M. Search for Related Content PubMed PubMed Citation Articles by Dernellis, J. Articles by Panaretou, M. Pubmed/NCBI databases Medline Plus Health Information High Blood Pressure Related Collections Other hypertension Clinical Studies Echocardiography

(Hypertension. 2005;45:426.)
© 2005 American Heart Association, Inc.

Original Articles

Aortic Stiffness Is an Independent Predictor of Progression to Hypertension in Nonhypertensive Subjects

From the Department of Cardiology, Vostanion Hospital, Mytilini, Greece.

Correspondence to Dr John Dernellis, 1 Kathigitou Karakatsani St, 811 00 Mytilini, Greece. E-mail dernellis{at}yahoo.gr

Abstract

Aortic stiffness may predict progression to hypertension beyond classic risk factors. In a longitudinal study, we assessed the predictive value of aortic stiffness on future hypertension in nonhypertensive subjects with blood pressure (BP) <140/90. Aortic stiffness was determined by echocardiography at baseline in 2512 subjects. The follow-up time was 4 years. A stepwise increase in hypertension incidence occurred across the male and older participants: 3.8% of young female individuals, 11.5% of young male, 26.1% of old female, and 58.8% of old male subjects progressed to hypertension over 4 years. In multivariate analysis, aortic stain, distensibility, and stiffness index (ß) remained significantly associated with the progression to future hypertension after adjustment to classic risk factors in men and women and in young and old populations. This study provides the first direct evidence to our knowledge in a longitudinal study that aortic stiffness is an independent predictor of progression to hypertension in nonhypertensive individuals.

Key Words: aorta • hypertension • stiffness

This article has been cited by other articles:

				A. O. Robb, N. L. Mills, J. N. Din, I. B.J. Smith, F. Paterson, D. E. Newby, and F. C. Denison Influence of the Menstrual Cycle, Pregnancy, and Preeclampsia on Arterial Stiffness Hypertension, June 1, 2009; 53(6): 952 - 958. [Abstract] [Full Text] [PDF]

				H. Guan, P. Wang, R. Hui, M. L. Edin, D. C. Zeldin, and D. W. Wang Adeno-Associated Virus-Mediated Human C-Reactive Protein Gene Delivery Causes Endothelial Dysfunction and Hypertension in Rats Clin. Chem., February 1, 2009; 55(2): 274 - 284. [Abstract] [Full Text] [PDF]

				G. Schillaci, G. V.L. De Socio, G. Pucci, M. R. Mannarino, J. Helou, M. Pirro, and E. Mannarino Aortic Stiffness in Untreated Adult Patients With Human Immunodeficiency Virus Infection Hypertension, August 1, 2008; 52(2): 308 - 313. [Abstract] [Full Text] [PDF]

				S. S. Najjar, A. Scuteri, V. Shetty, J. G. Wright, D. C. Muller, J. L. Fleg, H. P. Spurgeon, L. Ferrucci, and E. G. Lakatta Pulse Wave Velocity Is an Independent Predictor of the Longitudinal Increase in Systolic Blood Pressure and of Incident Hypertension in the Baltimore Longitudinal Study of Aging J. Am. Coll. Cardiol., April 8, 2008; 51(14): 1377 - 1383. [Abstract] [Full Text] [PDF]

				P. Ou, D. S. Celermajer, O. Raisky, O. Jolivet, F. Buyens, A. Herment, D. Sidi, D. Bonnet, and E. Mousseaux Angular (Gothic) aortic arch leads to enhanced systolic wave reflection, central aortic stiffness, and increased left ventricular mass late after aortic coarctation repair: Evaluation with magnetic resonance flow mapping J. Thorac. Cardiovasc. Surg., January 1, 2008; 135(1): 62 - 68. [Abstract] [Full Text] [PDF]

				N. Cheung, A. R. Sharrett, R. Klein, M. H. Criqui, F.M. A. Islam, K. J. Macura, M. F. Cotch, B. E.K. Klein, and T. Y. Wong Aortic Distensibility and Retinal Arteriolar Narrowing: The Multi-Ethnic Study of Atherosclerosis Hypertension, October 1, 2007; 50(4): 617 - 622. [Abstract] [Full Text] [PDF]

				P. Pauletto and M. Rattazzi Inflammation and hypertension: the search for a link Nephrol. Dial. Transplant., April 1, 2006; 21(4): 850 - 853. [Full Text] [PDF]

				J. Dernellis and M. Panaretou Effects of Levosimendan on Restrictive Left Ventricular Filling in Severe Heart Failure: A Combined Hemodynamic and Doppler Echocardiographic Study Chest, October 1, 2005; 128(4): 2633 - 2639. [Abstract] [Full Text] [PDF]

				S. S. Franklin Arterial Stiffness and Hypertension: A Two-Way Street? Hypertension, March 1, 2005; 45(3): 349 - 351. [Full Text] [PDF]