Published online before print September 6, 2005, doi: 10.1161/01.HYP.0000175476.26719.36
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Hypertension. 2005;46:1022.)
© 2005 American Heart Association, Inc.
Part 2 Original Articles |
Hypertension Produced by Reductions in Uterine Perfusion in the Pregnant Rat
Role of Tumor Necrosis Factor-
From the Department of Physiology and Obstetrics/Gynecology, University of Mississippi Medical Center, Jackson.
Correspondence to Joey P. Granger, PhD, Professor, Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216-4505. E-mail jgranger{at}physiology.umsmed.edu
Inflammatory cytokines such as tumor necrosis factor (TNF)- are elevated in preeclamptic women and are thought to be an important link between placental ischemia and endothelial dysfunction. The purpose of this study was to determine the role of TNF in mediating hypertension in response to chronic reductions in uterine perfusion (RUPPs) in pregnant rats. Arterial pressure was significantly higher in RUPP rats (138±1 mm Hg) than in pregnant rats (107±1 mm Hg). Serum TNF- levels in the RUPP rats were 17±4 pg/mL compared with 8±1 pg/mL in normal pregnant rats. To determine the long-term effects of a 2- to 3-fold elevation in plasma TNF- on renal and systemic hemodynamics in pregnant rats, we infused TNF- for 5 days at a rate of 50 ng/d during days 14 to 19 of gestation in pregnant rats. Serum levels were 7±2 pg/mL in the control pregnant rats and 14±2 pg/mL in the TNF-–treated pregnant rats. Mean arterial pressure was higher in the TNF-–treated pregnant rats (123±3 mm Hg) compared with pregnant controls (96±3 mm Hg) at day 19 of gestation. TNF- increased renal vascular resistance in pregnant rats by 182%. Renal plasma flow was 5.4±1.2 mL/min in the TNF-–treated group and 9.2±1.6 mL/min in the control group. Glomerular filtration rate was 1.7±0.4 mL/min in the TNF-–treated group and 2.6±0.4 mL/min in the control group. In summary, these data suggest that TNF- may play an important role in mediating the increased arterial pressure in response to chronic RUPPs in pregnant rats.
Key Words: kidney • pregnancy • hypertension, pregnancy • cytokines • endothelin
This article has been cited by other articles:
 |
|
 |
|
  D. D. Briana and A. Malamitsi-Puchner Reviews: Adipocytokines in Normal and Complicated Pregnancies Reproductive Sciences, October 1, 2009; 16(10): 921 - 937. [Abstract] [PDF]
|
|
|
|
 |
|
 B. LaMarca, G. Wallukat, M. Llinas, F. Herse, R. Dechend, and J. P. Granger Autoantibodies to the Angiotensin Type I Receptor in Response to Placental Ischemia and Tumor Necrosis Factor {alpha} in Pregnant Rats Hypertension, December 1, 2008; 52(6): 1168 - 1172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. LaMarca, J. Speed, L. Fournier, S. A. Babcock, H. Berry, K. Cockrell, and J. P. Granger Hypertension in Response to Chronic Reductions in Uterine Perfusion in Pregnant Rats: Effect of Tumor Necrosis Factor-{alpha} Blockade Hypertension, December 1, 2008; 52(6): 1161 - 1167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. D. LaMarca, J. Gilbert, and J. P. Granger Recent Progress Toward the Understanding of the Pathophysiology of Hypertension During Preeclampsia Hypertension, April 1, 2008; 51(4): 982 - 988. [Full Text] [PDF]
|
|
|
|
|
|
D. S. Hoffmann, C. J. Weydert, E. Lazartigues, W. J. Kutschke, M. F. Kienzle, J. E. Leach, J. A. Sharma, R. V. Sharma, and R. L. Davisson Chronic Tempol Prevents Hypertension, Proteinuria, and Poor Feto-Placental Outcomes in BPH/5 Mouse Model of Preeclampsia Hypertension, April 1, 2008; 51(4): 1058 - 1065. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Fasshauer, T. Waldeyer, J. Seeger, S. Schrey, T. Ebert, J. Kratzsch, U. Lossner, M. Bluher, M. Stumvoll, R. Faber, et al. Circulating high-molecular-weight adiponectin is upregulated in preeclampsia and is related to insulin sensitivity and renal function Eur. J. Endocrinol., February 1, 2008; 158(2): 197 - 201. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Gilbert, M. J. Ryan, B. B. LaMarca, M. Sedeek, S. R. Murphy, and J. P. Granger Pathophysiology of hypertension during preeclampsia: linking placental ischemia with endothelial dysfunction Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H541 - H550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Gilbert, S. A. Babcock, and J. P. Granger Hypertension Produced by Reduced Uterine Perfusion in Pregnant Rats Is Associated With Increased Soluble Fms-Like Tyrosine Kinase-1 Expression Hypertension, December 1, 2007; 50(6): 1142 - 1147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Sholook, J. S. Gilbert, M. H. Sedeek, M. Huang, R. L. Hester, and J. P. Granger Systemic hemodynamic and regional blood flow changes in response to chronic reductions in uterine perfusion pressure in pregnant rats Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2080 - H2084. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Xia, C. C. Zhou, S. M. Ramin, and R. E. Kellems Angiotensin Receptors, Autoimmunity, and Preeclampsia J. Immunol., September 15, 2007; 179(6): 3391 - 3395. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Xia, S. M. Ramin, and R. E. Kellems Potential Roles of Angiotensin Receptor-Activating Autoantibody in the Pathophysiology of Preeclampsia Hypertension, August 1, 2007; 50(2): 269 - 275. [Full Text] [PDF]
|
|
|
|
|
|
K. Tsukimori, H. Nakano, and N. Wake Difference in Neutrophil Superoxide Generation During Pregnancy Between Preeclampsia and Essential Hypertension Hypertension, June 1, 2007; 49(6): 1436 - 1441. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Gadonski, B. B. D. LaMarca, E. Sullivan, W. Bennett, D. Chandler, and J. P. Granger Hypertension Produced by Reductions in Uterine Perfusion in the Pregnant Rat: Role of Interleukin 6 Hypertension, October 1, 2006; 48(4): 711 - 716. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Granger An emerging role for inflammatory cytokines in hypertension Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H923 - H924. [Full Text] [PDF]
|
|
|
|
|
|
L. Roberts, B. B. D. LaMarca, L. Fournier, J. Bain, K. Cockrell, and J. P. Granger Enhanced Endothelin Synthesis by Endothelial Cells Exposed to Sera From Pregnant Rats With Decreased Uterine Perfusion Hypertension, March 1, 2006; 47(3): 615 - 618. [Abstract] [Full Text] [PDF]
|
|