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(Hypertension. 2006;47:467.)
© 2006 American Heart Association, Inc.

Original Articles

Imatinib Attenuates End-Organ Damage in Hypertensive Homozygous TGR(mRen2)27 Rats

Mark W.M. Schellings; Marcus Baumann; Rick E.W. van Leeuwen; Rudy F.J.J. Duisters; Suzanne H.P. Janssen; Blanche Schroen; Carine J. Peutz-Kootstra; Stephane Heymans; Yigal M. Pinto

From Experimental and Molecular Cardiology (M.W.M.S., R.E.W.v.L., R.F.J.J.D., S.H.P.J., B.S., S.H., Y.M.P.), Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, the Netherlands; Department of Pharmacology (M.B.), Maastricht University, the Netherlands; and Department of Pathology (C.J.P.-K.), University Hospital Maastricht, the Netherlands.

Correspondence to Yigal M. Pinto, MD, PhD, Experimental and Molecular Cardiology, Cardiovascular Research Institute Maastricht (CARIM), University Hospital Maastricht, P Debyelaan 25, 6202 AZ Maastricht, The Netherlands. E-mail y.pinto{at}cardio.azm.nl

Imatinib specifically inhibits receptor tyrosine kinase signaling and is clinically used to treat leukemia. Receptor tyrosine kinases not only mediate tumor growth but also initiate adverse signaling in heart failure. We investigated whether imatinib, by inhibiting the platelet-derived growth factor receptor-ß (PDGFRß), prevents cardiac and renal damage in TGR(mRen2)27 (Ren2) rats. Eight-week-old male homozygous Ren2 and Sprague Dawley rats were treated either with imatinib (30 mg/kg; STI-571) or placebo for 8 weeks (Ren2 n=12 for each group; Sprague Dawley n=6 for each group). Imatinib did not affect blood pressure or left ventricular (LV) hypertrophy in both groups. Imatinib attenuated the decline in fractional shortening (imatinib versus Ren2 placebo 45±4.5% versus 32±3%; n=7–11; P<0.05) and in diastolic function in Ren2 rats (baseline diastolic dP/dt corrected for systolic blood pressure Ren2 imatinib versus Ren2 placebo 38.6±0.67 versus 35.3±0.41 [1 · s^–1]; n=7–11; P<0.05). This was associated with decreased cardiac fibrosis and decreased activation of PDGFRß and extracellular signal-regulated kinase 1/2. Renal microvascular hypertrophy and perivascular fibrosis in Ren2 rats were significantly decreased by imatinib. In vitro, imatinib blocked angiotensin II-induced activation of the PDGFRß and significantly decreased fibroblast proliferation and collagen production. In conclusion, imatinib did not affect LV hypertrophy but attenuated the decline in cardiac function and reduced renal microvascular damage associated with reduced activation of the PDGFRß. The simultaneous improvement in both heart and kidneys suggests that inhibition of the PDGFRß has broad protective effects that may provide novel avenues for a blood pressure-independent protection against end-organ damage.

Key Words: platelet-derived growth factor • angiotensin II • hypertrophy • fibrosis

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Growth Factor Receptor Transactivation in Mediating End Organ Damage by Angiotensin II

Hiroyuki Suzuki and Satoru Eguchi
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