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(Hypertension. 2006;47:1003.)
© 2006 American Heart Association, Inc.

Original Articles

Telmisartan But Not Valsartan Increases Caloric Expenditure and Protects Against Weight Gain and Hepatic Steatosis

Ken Sugimoto; Nathan R. Qi; Ludmila Kazdová; Michal Pravenec; Toshio Ogihara; Theodore W. Kurtz

From the Department of Laboratory Medicine (K.S., N.R.Q., T.W.K.), University of California, San Francisco; Department of Geriatric Medicine (K.S., T.O.), Osaka University Graduate School of Medicine, Osaka, Japan; Institute for Clinical and Experimental Medicine (L.K.), Prague, Czech Republic; Institute of Physiology (M.P.), Czech Academy of Sciences, and the Center for Applied Genomics, Prague, Czech Republic.

Correspondence to Theodore W. Kurtz, Department of Laboratory Medicine, University of California San Francisco Clinical Laboratories, 185 Berry St, Ste 290, San Francisco, CA 94107. E-mail KurtzT{at}Labmed2.ucsf.edu

The potential effects of angiotensin II receptor blockers (ARBs) on adipose tissue biology and body weight are of considerable interest, because these agents are frequently used to treat hypertension in patients who are prone to visceral obesity, the metabolic syndrome, and diabetes. In rats fed a high-fat, high-carbohydrate diet, we compared the effects of 2 ARBs, telmisartan and valsartan, on body weight, food intake, energy expenditure, fat accumulation, fat cell size, and hepatic triglyceride levels. Telmisartan, but not valsartan, promoted increases in caloric expenditure and protected against dietary-induced weight gain. In the telmisartan-treated rats, absolute food intake, but not food intake adjusted for body weight, was lower than in valsartan-treated rats or controls. Telmisartan reduced the accumulation of visceral fat and decreased adipocyte size to a much greater extent than valsartan and was also associated with a significant reduction in hepatic triglyceride levels. Moreover, telmisartan, but not valsartan, increased the expression of both nuclear-encoded and mitochondrial-encoded genes in skeletal muscle known to play important roles in mitochondrial energy metabolism. Thus, in addition to a class effect of ARBs in modulating adipocyte size, these findings raise the possibility that certain molecules, like telmisartan, may have a particularly strong impact on fat cell volume and fat accumulation, as well as distinctive effects on energy metabolism, that may help protect against dietary-induced visceral obesity and weight gain.

Key Words: liver • hypertension, obesity • receptors, angiotensin II

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