Published online before print March 27, 2006, doi: 10.1161/01.HYP.0000215283.53943.39
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(Hypertension. 2006;47:827.)
© 2006 American Heart Association, Inc.
Editorial Commentaries |
Microvascular Plasticity and Experimental Heart Failure
From the Centre for Cardiovascular Research, Inserm Lariboisière, Paris, France.
Correspondence to Bernard Lévy, Centre for Cardiovascular Research, Inserm U689, 41 Bd de la Chapelle, 75010 Paris, France. E-mail levy@larib.inserm.fr
An extract of the first 250 words of the full text is provided, because this article has no abstract. |
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Introduction |
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Angiogenesis is an essential process in adulthood during wound healing and restoration of blood flow to injured tissues. Angiogenesis is regulated by a very sensitive interplay of growth factors and inhibitors; their imbalance can lead to very diverse diseases. Excessive angiogenesis is involved in malignant, diabetic retinopathy and inflammatory disorders (eg, rheumatoid arthritis, psoriasis, atherosclerosis). Conversely, insufficient angiogenesis may underlie conditions such as ischemic heart diseases, stroke, hypertension, and diabetes. Hence, during the evolution of these degenerative pathologies, inadequate blood vessel growth and insufficient microvascular density leads to poor circulation and tissue suffering or, ultimately, necrosis and death.1
In several physiological conditions, such as muscular exercise training and detraining, acclimatization to altitude, and aging, an adaptation of the microvascular network structure and function to new conditions has been reported.2,3 Interestingly, there is a close link between cerebral angiogenesis and learning; during cognitive decline in relation to senescence or degenerative cerebral diseases, microvascular density is decreased in specific cerebral areas. Specifically, there is a striking relationship between the capillary density, the cerebral tissue blood flow, the local glucose use, and other measures of neuronal signaling, such as the NA+/K+ ATPase (reviewed in Reference 4). Therefore, microvascular plasticity, defined as the ability of the arteriole and capillary network to adapt to the metabolic local conditions by proangiogenesis or antiangiogenesis processes, likely plays a key role in many tissue homeostatic processes.
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Microvasculature and Arterial Hypertension |
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In hypertension, the role of microcirculation (arteriolar and capillary) is of particular importance in increasing periph-eral resistance by decreasing the number
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