Published online before print April 3, 2006, doi: 10.1161/01.HYP.0000217128.41284.78
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Hypertension. 2006;47:840.)
© 2006 American Heart Association, Inc.
Original Articles |
Effects of Continuous Positive Airway Pressure Versus Supplemental Oxygen on 24-Hour Ambulatory Blood Pressure
From the Departments of Medicine (D.N., J.S.L., M.G.Z.), and Psychiatry (R.A.N., S.A.-I., P.J.M., J.E.D.), School of Medicine, University of California San Diego, San Diego, Calif.
Correspondence to Daniel Norman, Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Diego Medical Center, 200 West Arbor Dr, San Diego, CA 92103-8383. E-mail d1norman{at}ucsd.edu
Obstructive sleep apnea (OSA) is associated with recurrent episodes of nocturnal hypoxia and increased risk for development of systemic hypertension. Prior studies have been limited, however, in their ability to show reduction in blood pressure after continuous positive airway pressure (CPAP) therapy, and the effect of supplemental oxygen alone on blood pressure in OSA has not been evaluated. We performed a randomized, double-blind, placebo-controlled study comparing the effects of 2 weeks of CPAP versus sham-CPAP versus supplemental nocturnal oxygen on 24-hour ambulatory blood pressure in 46 patients with moderate-severe OSA. We found that 2 weeks of CPAP therapy resulted in a significant reduction in daytime mean arterial and diastolic blood pressure and nighttime systolic, mean, and diastolic blood pressure (all Ps <0.05). Although nocturnal supplemental oxygen therapy improved oxyhemoglobin saturation, it did not affect blood pressure. We conclude that CPAP therapy reduces both daytime and nighttime blood pressure in patients with OSA, perhaps through mechanisms other than improvement of nocturnal oxyhemoglobin saturation.
Key Words: apnea • blood pressure • oxygen
Related Article:
Hypertension 2006 47: 818-819.
This article has been cited by other articles:
 |
|
 |
|
  M. Kohler, J. C. T. Pepperell, B. Casadei, S. Craig, N. Crosthwaite, J. R. Stradling, and R. J. O. Davies CPAP and measures of cardiovascular risk in males with OSAS Eur. Respir. J., December 1, 2008; 32(6): 1488 - 1496. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G V Robinson, B A Langford, D M Smith, and J R Stradling Predictors of blood pressure fall with continuous positive airway pressure (CPAP) treatment of obstructive sleep apnoea (OSA) Thorax, October 1, 2008; 63(10): 855 - 859. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. Phillips, B. Yee, Q. Yang, A. T. Villaneuva, J. Hedner, N. Berend, and R. Grunstein Effects of Continuous Positive Airway Pressure Treatment and Withdrawal in Patients With Obstructive Sleep Apnea on Arterial Stiffness and Central BP Chest, July 1, 2008; 134(1): 94 - 100. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Williams The Year in Hypertension J. Am. Coll. Cardiol., May 6, 2008; 51(18): 1803 - 1817. [Full Text] [PDF]
|
|
|
|
|
|
D. Sorajja, A. S. Gami, V. K. Somers, T. R. Behrenbeck, A. Garcia-Touchard, and F. Lopez-Jimenez Independent Association Between Obstructive Sleep Apnea and Subclinical Coronary Artery Disease Chest, April 1, 2008; 133(4): 927 - 933. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kapa, F. H. Sert Kuniyoshi, and V. K. Somers Sleep Apnea and Hypertension: Interactions and Implications for Management Hypertension, March 1, 2008; 51(3): 605 - 608. [Full Text] [PDF]
|
|
|
|
 |
|
 M. H. Sanders, J. M. Montserrat, R. Farre, and R. J. Givelber Positive Pressure Therapy: A Perspective on Evidence-based Outcomes and Methods of Application Proceedings of the ATS, February 15, 2008; 5(2): 161 - 172. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J Amit Benjamin and K E Lewis Sleep-disordered breathing and cardiovascular disease Postgrad. Med. J., January 1, 2008; 84(987): 15 - 22. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Buyse, J. Hedner, and the participants of working group 2 Sleep apnoea, hypertension and vascular disease: where are we now? Eur. Respir. Rev., December 1, 2007; 16(106): 169 - 182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Bazzano, Z. Khan, K. Reynolds, and J. He Effect of Nocturnal Nasal Continuous Positive Airway Pressure on Blood Pressure in Obstructive Sleep Apnea Hypertension, August 1, 2007; 50(2): 417 - 423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Floras and T. D. Bradley Treating Obstructive Sleep Apnea: Is There More to the Story Than 2 Millimeters of Mercury? Hypertension, August 1, 2007; 50(2): 289 - 291. [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Montserrat, F. Garcia-Rio, and F. Barbe Diagnostic and Therapeutic Approach to Nonsleepy Apnea Am. J. Respir. Crit. Care Med., July 1, 2007; 176(1): 6 - 9. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Haentjens, A. Van Meerhaeghe, A. Moscariello, S. De Weerdt, K. Poppe, A. Dupont, and B. Velkeniers The Impact of Continuous Positive Airway Pressure on Blood Pressure in Patients With Obstructive Sleep Apnea Syndrome: Evidence From a Meta-analysis of Placebo-Controlled Randomized Trials Arch Intern Med, April 23, 2007; 167(8): 757 - 764. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. T. McNicholas, M. R. Bonsignore, and the Management Committee of EU COST ACTION B26 Sleep apnoea as an independent risk factor for cardiovascular disease: current evidence, basic mechanisms and research priorities Eur. Respir. J., January 1, 2007; 29(1): 156 - 178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. H. Sert Kuniyoshi and V. K. Somers Sleep Apnea in Hypertension: When, How, and Why Should We Treat? Hypertension, May 1, 2006; 47(5): 818 - 819. [Full Text] [PDF]
|
|