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(Hypertension. 2007;49:597.)
© 2007 American Heart Association, Inc.

State-of-the-Art Lecture

Genetic Susceptibility to Essential Hypertension

Insight From Angiotensinogen

From the Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City.

Correspondence to Jean-Marc Lalouel, Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112. E-mail jml{at}genetics.utah.edu

Although progress in the genetics of essential hypertension may seem disappointing, it has considerable potential in defining research directions that will ultimately translate into clinical practice. The hypothesis that genetic variation at the angiotensinogen locus impacts on individual susceptibility to develop essential hypertension has motivated a substantial body of research by us and many others. We examine how analyses of the mechanisms by which variation in angiotensinogen expression may contribute to disease susceptibility and may have arisen in human populations have progressed in recent years. Although the objective of personalized medicine is still in the future, a genetic hypothesis based on human variation can uniquely empower functional genomics approaches to reach such an ultimate goal.

Key Words: genetics • essential hypertension • high blood pressure • angiotensinogen • renin

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