Hypertension, Vol 5, 100-104, Copyright © 1983 by American Heart Association
DS Goldstein, CR Lake, B Chernow, MG Ziegler, MD Coleman, AA Taylor, JR Mitchell, IJ Kopin and HR Keiser
We compared venous plasma norepinephrine (NE) concentrations in 191
resting, supine patients with essential hypertension and 129 normotensive
controls. Among normotensives, plasma NE increased significantly with age,
but among hypertensives, no age-related increase occurred, due to
relatively high NE values among young hypertensives. When patients and
controls less than 40 years old were considered, hypertensives showed
significantly higher plasma NE than the controls (317 vs 245 pg/ml, t =
3.15, p less than 0.01); but above the age of 40 years, no significant
hypertensive-normotensive difference was obtained. These results, predicted
by recent literature reviews, help to resolve the persistent controversy
about sympathetic neural activity in essential hypertension, since such
activity appears to be abnormal mainly in young patients. The data are
consistent with increased sympathetic nervous system activity in the early
stages of essential hypertension.
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Age-dependence of hypertensive-normotensive differences in plasma norepinephrine
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