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(Hypertension. 2007;50:607.)
© 2007 American Heart Association, Inc.

Editorial Commentaries

Still Building on Candidate-Gene Strategy in Hypertension?

Frédérique Tesson; Frans H.H. Leenen

From the University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

Correspondence to Frédérique Tesson, University of Ottawa Heart Institute, 40 Ruskin St, Ottawa, Ontario, Canada K1Y 4W7. E-mail ftesson@ottawaheart.ca

An extract of the first 250 words of the full text is provided, because this article has no abstract.

In the general hypertensive population, blood pressure (BP) is a multifactorial trait, and it appears that hypertension results from increments in BP from a number of contributing variants and their interactions with the environment. In spite of numerous linkage and association studies of candidate genes for BP per se, or BP response to salt, the genetic network responsible for BP variation remains elusive.

In recent years, several genome-wide scans have been performed in different populations around the world. The results have been rather variable, which can be attributed to different ethnic origins of the populations; often small sample sizes; lack of stratification by gender, age, and other determinants of BP; and limited assessment of the phenotype. However, 6 independent studies have reported evidence of linkage between systolic BP and chromosome 16p12 that includes SCNN1B and SCNN1G.¹ In the present issue of Hypertension, Büsst et al¹ focus attention on the influence of polymorphisms in SCNN1G, the gene encoding the -subunit of epithelial sodium channel (ENaC), on systolic BP. Three single nucleotide polymorphisms, considered individually or as a haplotype, appeared to be associated with systolic BP in logistic regression analyses adjusted for age, sex, and body mass index.¹ The study was carried out in a white Australian population. This article is particularly attractive, because it confirms the involvement of "natural" susceptibility genes in BP levels. This is a good example of the importance of performing a comprehensive "gene-scan" analysis to determine whether a candidate gene is associated with the . . . [Full Text of this Article]

Related Article:

Selective Genotyping Reveals Association Between the Epithelial Sodium Channel -Subunit and Systolic Blood Pressure

Cara J. Büsst, Katrina J. Scurrah, Justine A. Ellis, and Stephen B. Harrap
Hypertension 2007 50: 672-678. [Abstract] [Full Text] [PDF]

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